論文 - 詳細
| RRC ID | 44297 |
|---|---|
| 著者 | Sogawa N, Hirai K, Sogawa C, Ohyama K, Miyazaki I, Tsukamoto G, Asanuma M, Sasaki A, Kitayama S. |
| タイトル | Protective effect of cepharanthin on cisplatin-induced renal toxicity through metallothionein expression. |
| ジャーナル | Life Sci |
| Abstract |
AIMS:Cisplatin (CDDP) is a potent anticancer agent, but severe renal toxicity can limit its use. We investigated the protective effect of cepharanthin (CE), a biscoclaurin alkaloid, on the renal toxicity of CDDP. MAIN METHODS:Mice were given CDDP along with CE. Effects of CE on CDDP toxicity were investigated by assaying markers of renal toxicity together with MT expression, and by histopathological examination of the kidney. MT-null mice were also examined. KEY FINDINGS:CE induced expression of metallothionein (MT). Pre-administration of CE attenuated an increase in blood urea nitrogen (BUN) concentrations after the CDDP injection. A histochemical analysis demonstrated protection against CDDP-induced necrocytosis of kidney tissues by CE. The protective effect of CE did not occur in the MT-null mice. SIGNIFICANCE:Pretreatment with CE may reduce the renal toxicity of CDDP through expression of MT. |
| 巻・号 | 92(12) |
| ページ | 727-32 |
| 公開日 | 2013-4-9 |
| DOI | 10.1016/j.lfs.2013.01.031 |
| PII | S0024-3205(13)00072-6 |
| PMID | 23399700 |
| MeSH | Animals Antineoplastic Agents / toxicity* Antineoplastic Agents, Phytogenic / therapeutic use* Benzylisoquinolines / therapeutic use* COS Cells Cell Line Chlorocebus aethiops Cisplatin / toxicity* Kidney / drug effects Kidney / metabolism Kidney / pathology Kidney Diseases / chemically induced* Kidney Diseases / genetics Kidney Diseases / prevention & control* Male Metallothionein / genetics* Mice Mice, Inbred C57BL RNA, Messenger / genetics Up-Regulation / drug effects |
| IF | 3.647 |
| 引用数 | 9 |
| WOS 分野 | MEDICINE, RESEARCH & EXPERIMENTAL PHARMACOLOGY & PHARMACY |
| リソース情報 | |
| ヒト・動物細胞 | COS-7(RCB0539) MDCK(RCB0995) |