論文 - 詳細
| RRC ID | 44310 |
|---|---|
| 著者 | Ródenas-Rochina J, Ribelles JL, Lebourg M. |
| タイトル | Comparative study of PCL-HAp and PCL-bioglass composite scaffolds for bone tissue engineering. |
| ジャーナル | J Mater Sci Mater Med |
| Abstract |
The aim of this work is to compare the effect of hydroxyapatite (HAp) or bioglass (BG) nanoparticles in a polycaprolactone composite scaffold aimed to bone regeneration. To allow a comparison of the influence of both types of fillers, scaffolds made of PCL or composites containing up to 20 % by weight HAp or BG were obtained. Scaffolds showed acceptable mechanical properties for its use and high interconnected porosity apt for cellular colonization. To study the effect of the different materials on pre-osteoblast cells differentiation, samples with 5 % mineral reinforcement, were cultured for up to 28 days in osteogenic medium. Cells proliferated in all scaffolds. Nevertheless, differentiation levels for the selected markers were higher in pure PCL scaffolds than in the composites; inclusion of bioactive particles showed no positive effects on cell differentiation. In osteogenic culture conditions, the presence of bioactive particles is thus not necessary in order to observe good differentiation. |
| 巻・号 | 24(5) |
| ページ | 1293-308 |
| 公開日 | 2013-5-1 |
| DOI | 10.1007/s10856-013-4878-5 |
| PMID | 23417519 |
| MeSH | Animals Bone and Bones* / cytology Bone and Bones* / drug effects Bone and Bones* / physiology Cells, Cultured Ceramics / chemical synthesis Ceramics / chemistry* Ceramics / pharmacology Compressive Strength Durapatite / chemistry* Durapatite / pharmacology Elastic Modulus Materials Testing Mice Nanocomposites / chemistry Osteoblasts / cytology Osteoblasts / drug effects Osteoblasts / physiology Polyesters / chemistry* Polyesters / pharmacology Porosity Tissue Engineering / instrumentation* Tissue Scaffolds / chemistry* |
| IF | 2.489 |
| 引用数 | 44 |
| WOS 分野 | ENGINEERING, BIOMEDICAL MATERIALS SCIENCE, BIOMATERIALS |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 12 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | MC3T3-E1(RCB1126) |