| RRC ID |
44310
|
| 著者 |
Ródenas-Rochina J, Ribelles JL, Lebourg M.
|
| タイトル |
Comparative study of PCL-HAp and PCL-bioglass composite scaffolds for bone tissue engineering.
|
| ジャーナル |
J Mater Sci Mater Med
|
| Abstract |
The aim of this work is to compare the effect of hydroxyapatite (HAp) or bioglass (BG) nanoparticles in a polycaprolactone composite scaffold aimed to bone regeneration. To allow a comparison of the influence of both types of fillers, scaffolds made of PCL or composites containing up to 20 % by weight HAp or BG were obtained. Scaffolds showed acceptable mechanical properties for its use and high interconnected porosity apt for cellular colonization. To study the effect of the different materials on pre-osteoblast cells differentiation, samples with 5 % mineral reinforcement, were cultured for up to 28 days in osteogenic medium. Cells proliferated in all scaffolds. Nevertheless, differentiation levels for the selected markers were higher in pure PCL scaffolds than in the composites; inclusion of bioactive particles showed no positive effects on cell differentiation. In osteogenic culture conditions, the presence of bioactive particles is thus not necessary in order to observe good differentiation.
|
| 巻・号 |
24(5)
|
| ページ |
1293-308
|
| 公開日 |
2013-5-1
|
| DOI |
10.1007/s10856-013-4878-5
|
| PMID |
23417519
|
| MeSH |
Animals
Bone and Bones* / cytology
Bone and Bones* / drug effects
Bone and Bones* / physiology
Cells, Cultured
Ceramics / chemical synthesis
Ceramics / chemistry*
Ceramics / pharmacology
Compressive Strength
Durapatite / chemistry*
Durapatite / pharmacology
Elastic Modulus
Materials Testing
Mice
Nanocomposites / chemistry
Osteoblasts / cytology
Osteoblasts / drug effects
Osteoblasts / physiology
Polyesters / chemistry*
Polyesters / pharmacology
Porosity
Tissue Engineering / instrumentation*
Tissue Scaffolds / chemistry*
|
| IF |
2.489
|
| 引用数 |
44
|
|
WOS 分野
|
ENGINEERING, BIOMEDICAL
MATERIALS SCIENCE, BIOMATERIALS
|
| リソース情報 |
| ヒト・動物細胞 |
MC3T3-E1(RCB1126) |
