| RRC ID |
44385
|
| Author |
Kumano-Kuramochi M, Xie Q, Kajiwara S, Komba S, Minowa T, Machida S.
|
| Title |
Lectin-like oxidized LDL receptor-1 is palmitoylated and internalizes ligands via caveolae/raft-dependent endocytosis.
|
| Journal |
Biochem Biophys Res Commun
|
| Abstract |
Lectin-like oxidized low-density lipoprotein (LDL) receptor-1 (LOX-1) is an endothelial scavenger receptor that is important for oxidized low-density lipoprotein uptake. LOX-1 functions as an oligomer; however, little is known about the oligomeric complex and ligand processing after recognition by LOX-1. Here, we found that LOX-1 recognized and internalized ligands through the caveolae/raft-dependent endocytosis pathway in human coronary artery endothelial cells. Furthermore, we demonstrated that LOX-1 was palmitoylated and that both cysteine 36 and cysteine 46 were necessary for the recruitment of LOX-1 into raft microdomains and for its ligand uptake ability.
|
| Volume |
434(3)
|
| Pages |
594-9
|
| Published |
2013-5-10
|
| DOI |
10.1016/j.bbrc.2013.03.120
|
| PII |
S0006-291X(13)00599-8
|
| PMID |
23583401
|
| MeSH |
Caveolae / metabolism*
Cells, Cultured
Endocytosis* / drug effects
Genistein / pharmacology
Humans
Ligands
Lipoylation
Nystatin / pharmacology
Scavenger Receptors, Class E / metabolism*
|
| IF |
2.985
|
| Times Cited |
7
|
|
WOS Category
|
BIOPHYSICS
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| Resource |
| Human and Animal Cells |
|
