RRC ID 44398
Author Uchida M, Oyanagi E, Miyachi M, Yamauchi A, Yano H.
Title Relationship between macrophage differentiation and the chemotactic activity toward damaged myoblast cells.
Journal J Immunol Methods
Abstract We investigated the effect of macrophage differentiation on the chemotactic activity to invade local damaged myoblasts using in vitro models of muscle injury. We found that: 1) the chemotactic activity of macrophages toward areas of damaged myoblasts might be induced more by live myoblasts than dead ones, 2) the chemotactic activity of macrophages is not due to velocity, but depends on the directionality toward damaged myoblast cells, and 3) macrophage differentiation strongly influence the chemotactic activity toward damaged myoblast cells through the expression of CCR2 and/or F-actin.
Volume 393(1-2)
Pages 61-9
Published 2013-7-31
DOI 10.1016/j.jim.2013.04.007
PII S0022-1759(13)00128-2
PMID 23603617
MeSH Actins / immunology Actins / metabolism Animals Cell Differentiation / immunology Cell Line Chemokine CCL2 / immunology Chemokine CCL2 / metabolism Chemotaxis / immunology* Macrophages / immunology* Macrophages / metabolism Macrophages / pathology* Mice Muscle, Skeletal / immunology Muscle, Skeletal / metabolism Muscle, Skeletal / pathology Muscular Diseases / immunology Muscular Diseases / metabolism Muscular Diseases / pathology Myoblasts / immunology* Myoblasts / metabolism Myoblasts / pathology* Receptors, CCR2 / immunology Receptors, CCR2 / metabolism
IF 1.913
Times Cited 2
Human and Animal Cells