| RRC ID |
44428
|
| 著者 |
Shigeoka M, Urakawa N, Nakamura T, Nishio M, Watajima T, Kuroda D, Komori T, Kakeji Y, Semba S, Yokozaki H.
|
| タイトル |
Tumor associated macrophage expressing CD204 is associated with tumor aggressiveness of esophageal squamous cell carcinoma.
|
| ジャーナル |
Cancer Sci
|
| Abstract |
Tumor associated macrophages (TAMs) are the most abundant cancer stromal cells educated by tumor microenvironment to acquire trophic functions facilitating angiogenesis, matrix breakdown and cancer cell motility. Tumor associated macrophages have anti-inflammatory properties or "alternatively" activated (M2) phenotype expressing CD204 and/or CD163. To know the role of TAMs in the growth and progression of esophageal squamous cell carcinomas (ESCCs), we calculated intratumoral CD204, CD163 or CD68 expressing macrophage count (MϕC) and CD34-positive microvessel density (MVD) by immunohistochemistry in 70 cases of surgically resected ESCCs and compared them with the clinicopathological factors and prognosis of patients. MϕC had positive linear association with MVD. High CD204(+) MϕC were significantly correlated with more malignant phenotypes including depth of tumor invasion, lymph and blood vessel invasion, lymph node metastasis as well as clinical stages. On the other hand, CD163(+) MϕC did not associate with these clinicopathological factors with the exception of depth of tumor invasion and blood vessel invasion. Patients with high CD204(+) MϕC ESCCs showed poor disease-free survival (P = 0.021). Conditioned media of five ESCC cell lines (TE-8, -9, -10, -11 and -15) induced mRNA as well as protein expression of CD204 but not of CD163 with upregulation of vascular endothelial growth factor-A mRNA in TPA treated human acute monocytic leukemia cell line THP-1. These results overall indicate that CD204 is a useful marker for TAMs contributing to the angiogenesis, progression and prognosis of ESCCs whose specific tumor microenvironment may educate macrophages to be CD204(+) M2 TAMs.
|
| 巻・号 |
104(8)
|
| ページ |
1112-9
|
| 公開日 |
2013-8-1
|
| DOI |
10.1111/cas.12188
|
| PMID |
23648122
|
| PMC |
PMC7657117
|
| MeSH |
Aged
Aged, 80 and over
Carcinoma, Squamous Cell / blood supply
Carcinoma, Squamous Cell / genetics*
Carcinoma, Squamous Cell / metabolism
Carcinoma, Squamous Cell / pathology*
Cell Line, Tumor
Disease Progression
Esophageal Neoplasms / blood supply
Esophageal Neoplasms / genetics*
Esophageal Neoplasms / metabolism
Esophageal Neoplasms / pathology*
Esophageal Squamous Cell Carcinoma
Female
Humans
Immunohistochemistry
Leukemia, Monocytic, Acute / genetics
Leukemia, Monocytic, Acute / metabolism
Leukemia, Monocytic, Acute / pathology
Lymphatic Metastasis
Macrophages / metabolism*
Male
Middle Aged
Neovascularization, Pathologic / genetics
Neovascularization, Pathologic / metabolism
Neovascularization, Pathologic / pathology
Prognosis
RNA, Messenger / genetics
Scavenger Receptors, Class A / biosynthesis*
Scavenger Receptors, Class A / genetics
Scavenger Receptors, Class A / metabolism
Tumor Microenvironment
Vascular Endothelial Growth Factor A / genetics
Vascular Endothelial Growth Factor A / metabolism
|
| IF |
4.966
|
| 引用数 |
91
|
|
WOS 分野
|
ONCOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
TE-8(RCB2098)
TE-9(RCB1988)
TE-10(RCB2099)
TE-11(RCB2100)
TE-15(RCB19519 |
