論文 - 詳細
| RRC ID | 44434 |
|---|---|
| 著者 | Kono H, Nakamura M, Ohtsuka T, Nagayoshi Y, Mori Y, Takahata S, Aishima S, Tanaka M. |
| タイトル | High expression of microRNA-155 is associated with the aggressive malignant behavior of gallbladder carcinoma. |
| ジャーナル | Oncol Rep |
| Abstract |
The prognosis of gallbladder cancer (GBC) remains poor despite recent advances in diagnostics and therapeutic strategies. Although the role of microRNAs (miRs) in GBC have not been well documented, miR-155 is known to be associated with inflammation-associated carcinogenesis in various types of cancers. The aim of this study was to investigate the clinical significance of miR-155 expression and the biological functions of miR-155 in GBC. The expression levels of miR-155 in surgically resected GBCs and gallbladders with pancreaticobiliary maljunction (PBM) were assessed by quantitative reverse transcription-polymerase chain reaction. The relationship between the expression levels of miR-155 and clinicopathological features of GBCs was analyzed. Human GBC cell lines were transfected with miR-155 inhibitors or mimics, and the effects on proliferation and invasion were assessed. miR-155 was significantly overexpressed in GBCs when compared with that in gallbladders with PBM (p=0.007) and normal gallbladders (p=0.04). The high expression level of miR-155 in GBCs was significantly associated with the presence of lymph node metastasis (p=0.01) and a poor prognosis (p=0.02). In vitro assays showed that aberrant expression of miR-155 significantly enhanced GBC cell proliferation and invasion. In conclusion, high miR-155 expression correlates with the aggressive behavior of GBCs, and miR-155 may become a prognostic marker and therapeutic target for GBC. |
| 巻・号 | 30(1) |
| ページ | 17-24 |
| 公開日 | 2013-7-1 |
| DOI | 10.3892/or.2013.2443 |
| PMID | 23660842 |
| PMC | PMC3729208 |
| MeSH | Adult Aged Biomarkers, Tumor / genetics Cell Line, Tumor Cell Proliferation Female Gallbladder / cytology Gallbladder Neoplasms / genetics* Gene Expression Gene Expression Regulation, Neoplastic Humans Inflammation / genetics Lymphatic Metastasis / genetics* Male MicroRNAs / biosynthesis MicroRNAs / genetics* Middle Aged Neoplasm Invasiveness / genetics* Prognosis |
| IF | 3.417 |
| 引用数 | 38 |
| WOS 分野 | ONCOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | G-415(RCB2640) |