論文 - 詳細
| RRC ID | 44481 |
|---|---|
| 著者 | Monzen S, Takimura K, Kashiwakura I, Hosokawa Y. |
| タイトル | Acute promyelocytic leukemia mutated to radioresistance suppressed monocyte lineage differentiation by phorbol 12-myristate 13-acetate. |
| ジャーナル | Leuk Res |
| Abstract |
Induction of myeloid differentiation in radioresistant HL60 cells (Res-HL60) was examined to clarify the developmental mechanism of radioresistant leukemia. Compared to wild-type HL60 cells (Wt-HL60), Res-HL60 were smaller and strongly expressed CD38. Under all-trans retinoic acid (ATRA) stimulation, Res-HL60 continued to proliferate slowly and with similar level of CD11b expression to Wt-HL60. Phorbol 12-myristate 13-acetate (PMA) strongly suppressed proliferation of Res-HL60, downregulated CD14, and affected mRNA expression. These results suggested that the specific myeloid differentiation of Res-HL60 suppressed monocyte lineage by ATRA and PMA occurred through regulation of mRNA expression. |
| 巻・号 | 37(9) |
| ページ | 1162-9 |
| 公開日 | 2013-9-1 |
| DOI | 10.1016/j.leukres.2013.04.027 |
| PII | S0145-2126(13)00149-5 |
| PMID | 23773897 |
| MeSH | Antineoplastic Agents / pharmacology Biomarkers, Tumor / genetics Biomarkers, Tumor / metabolism Carcinogens / pharmacology Cell Differentiation / drug effects* Cell Differentiation / radiation effects* Cell Lineage* Flow Cytometry Gene Expression Profiling HL-60 Cells Humans Leukemia, Promyelocytic, Acute / drug therapy Leukemia, Promyelocytic, Acute / pathology* Leukemia, Promyelocytic, Acute / radiotherapy Monocytes / cytology Monocytes / drug effects Monocytes / radiation effects Mutation / genetics* Oligonucleotide Array Sequence Analysis Radiation Tolerance / drug effects* Tetradecanoylphorbol Acetate / pharmacology* Tretinoin / pharmacology Tumor Cells, Cultured X-Rays |
| IF | 2.214 |
| 引用数 | 3 |
| WOS 分野 | HEMATOLOGY ONCOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ヒト・動物細胞 | HL60(RCB0041) |