| RRC ID |
44481
|
| 著者 |
Monzen S, Takimura K, Kashiwakura I, Hosokawa Y.
|
| タイトル |
Acute promyelocytic leukemia mutated to radioresistance suppressed monocyte lineage differentiation by phorbol 12-myristate 13-acetate.
|
| ジャーナル |
Leuk Res
|
| Abstract |
Induction of myeloid differentiation in radioresistant HL60 cells (Res-HL60) was examined to clarify the developmental mechanism of radioresistant leukemia. Compared to wild-type HL60 cells (Wt-HL60), Res-HL60 were smaller and strongly expressed CD38. Under all-trans retinoic acid (ATRA) stimulation, Res-HL60 continued to proliferate slowly and with similar level of CD11b expression to Wt-HL60. Phorbol 12-myristate 13-acetate (PMA) strongly suppressed proliferation of Res-HL60, downregulated CD14, and affected mRNA expression. These results suggested that the specific myeloid differentiation of Res-HL60 suppressed monocyte lineage by ATRA and PMA occurred through regulation of mRNA expression.
|
| 巻・号 |
37(9)
|
| ページ |
1162-9
|
| 公開日 |
2013-9-1
|
| DOI |
10.1016/j.leukres.2013.04.027
|
| PII |
S0145-2126(13)00149-5
|
| PMID |
23773897
|
| MeSH |
Antineoplastic Agents / pharmacology
Biomarkers, Tumor / genetics
Biomarkers, Tumor / metabolism
Carcinogens / pharmacology
Cell Differentiation / drug effects*
Cell Differentiation / radiation effects*
Cell Lineage*
Flow Cytometry
Gene Expression Profiling
HL-60 Cells
Humans
Leukemia, Promyelocytic, Acute / drug therapy
Leukemia, Promyelocytic, Acute / pathology*
Leukemia, Promyelocytic, Acute / radiotherapy
Monocytes / cytology
Monocytes / drug effects
Monocytes / radiation effects
Mutation / genetics*
Oligonucleotide Array Sequence Analysis
Radiation Tolerance / drug effects*
Tetradecanoylphorbol Acetate / pharmacology*
Tretinoin / pharmacology
Tumor Cells, Cultured
X-Rays
|
| IF |
2.214
|
| 引用数 |
3
|
|
WOS 分野
|
HEMATOLOGY
ONCOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
HL60(RCB0041) |
