| RRC ID |
44521
|
| 著者 |
Yamamoto Y, Konishi H, Ichikawa D, Arita T, Shoda K, Komatsu S, Shiozaki A, Ikoma H, Fujiwara H, Okamoto K, Ochiai T, Inoue J, Inazawa J, Otsuji E.
|
| タイトル |
Significance of GSTP1 for predicting the prognosis and chemotherapeutic efficacy in esophageal squamous cell carcinoma.
|
| ジャーナル |
Oncol Rep
|
| Abstract |
Glutathione S-transferases (GSTs) have been reported to be activated in several types of cancers, including esophageal squamous cell carcinoma (ESCC). The aim of the present study was to investigate whether GSTP1 protein expression is a useful predictor of the clinical outcome or drug resistance in ESCC. Immunohistochemistry was conducted with 75 ESCC resected specimens using a monoclonal antibody against GSTP1. The patients were divided into two groups according to the degree of GSTP1 staining, and the relationship between the GSTP1 level and the clinicopathological features was examined. Seventy-five patients were divided into low (grade 1, n=36) and high (grade 2, n=39) GSTP1 expression groups. The overall survival was significantly worse in the grade 2 patients than in the grade 1 patients (5‑year survival rate, 78.5 vs. 51.2%; p=0.027). Cox proportional hazard analysis revealed that macroscopic type 3 or 4 disease (p=0.001), lymph node metastasis (p=0.010), and high GSTP1 expression (p=0.029) were independent predictors of a poor prognosis. With regard to the subgroup analysis among the 31 patients undergoing adjuvant chemotherapy, the grade 2 patients had a worse prognosis than did the grade 1 patients (5‑year survival rate, 45.0 vs. 81.8%; p=0.081). This tendency was not observed in the subgroup without adjuvant chemotherapy (5‑year survival rate, 51.7 vs. 59.9%; p=0.979). In conclusion, the GSTP1 expression is a good predictor of prognosis, and it may be closely related to the chemotherapeutic efficacy of 5-FU plus cisplatin in ESCC patients.
|
| 巻・号 |
30(4)
|
| ページ |
1687-94
|
| 公開日 |
2013-10-1
|
| DOI |
10.3892/or.2013.2606
|
| PMID |
23842854
|
| MeSH |
Aged
Antimetabolites, Antineoplastic / therapeutic use
Carcinoma, Squamous Cell / drug therapy*
Carcinoma, Squamous Cell / mortality*
Carcinoma, Squamous Cell / pathology
Cell Line, Tumor
Chemotherapy, Adjuvant
Cisplatin / therapeutic use
Esophageal Neoplasms / drug therapy*
Esophageal Neoplasms / mortality*
Esophageal Neoplasms / pathology
Esophageal Squamous Cell Carcinoma
Female
Fluorouracil / therapeutic use
Glutathione S-Transferase pi / biosynthesis
Glutathione S-Transferase pi / metabolism*
Humans
Lymphatic Metastasis
Male
Prognosis
Survival
Treatment Outcome
|
| IF |
3.417
|
| 引用数 |
11
|
|
WOS 分野
|
ONCOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
|
