| RRC ID |
44548
|
| Author |
Tanaka Y, Suenaga T, Matsumoto M, Seya T, Arase H.
|
| Title |
Herpesvirus 6 glycoproteins B (gB), gH, gL, and gQ are necessary and sufficient for cell-to-cell fusion.
|
| Journal |
J Virol
|
| Abstract |
The human herpesvirus 6 (HHV-6) envelope glycoprotein gH/gL/gQ1/gQ2 complex associates with host cell CD46 as its cellular receptor. Although gB has been suggested to be involved in HHV-6 infection, its function in membrane fusion has remained unclear. Here, we have developed an HHV-6A (strain GS)and HHV-6B (strain Z29) virus-free cell-to-cell fusion assay and demonstrate that gB and the gH/gL/gQ1/gQ2 complex are the minimum components required for membrane fusion by HHV-6.
|
| Volume |
87(19)
|
| Pages |
10900-3
|
| Published |
2013-10-1
|
| DOI |
10.1128/JVI.01427-13
|
| PII |
JVI.01427-13
|
| PMID |
23885076
|
| PMC |
PMC3807422
|
| MeSH |
Cell Fusion*
Cells, Cultured
DNA, Viral / genetics
Flow Cytometry
Glycoproteins / classification
Glycoproteins / genetics
Glycoproteins / metabolism*
Herpesviridae Infections / genetics
Herpesviridae Infections / metabolism*
Herpesviridae Infections / virology
Herpesvirus 6, Human / physiology*
Humans
Kidney / cytology
Kidney / metabolism
Kidney / virology
Luciferases / metabolism
Membrane Cofactor Protein / genetics
Membrane Cofactor Protein / metabolism*
Membrane Fusion*
Polymerase Chain Reaction
|
| IF |
4.501
|
| Times Cited |
12
|
|
WOS Category
|
VIROLOGY
|
| Resource |
| Human and Animal Cells |
|
