論文 - 詳細
RRC ID | 44585 |
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著者 | Pepić I, Lovrić J, Cetina-Čižmek B, Reichl S, Filipović-Grčić J. |
タイトル | Toward the practical implementation of eye-related bioavailability prediction models. |
ジャーナル | Drug Discov Today |
Abstract |
The development and registration of reformulated ophthalmic products (OPs) requires eye-related bioavailability (BA) assessments. Common BA algorithms associated with other routes of application, such as the oral route, cannot be easily applied to eye-related BA testing. Here, we provide an analysis of the current literature and suggestions for further directions in the development of high-capacity, cost-effective, and highly predictive nonclinical models of eye-related drug BA. One, or a combination of these models, has the potential for routine use in research laboratories and/or the pharmaceutical industry to overcome various obstacles in reformulated OP development and registration. |
巻・号 | 19(1) |
ページ | 31-44 |
公開日 | 2014-1-1 |
DOI | 10.1016/j.drudis.2013.08.002 |
PII | S1359-6446(13)00265-1 |
PMID | 23948143 |
MeSH | Administration, Ophthalmic Animals Biological Availability Eye / drug effects* Eye / metabolism* Humans Models, Biological* Permeability / drug effects Pharmaceutical Preparations / administration & dosage* Pharmaceutical Preparations / metabolism* |
IF | 7.321 |
引用数 | 25 |
WOS 分野 | PHARMACOLOGY & PHARMACY |
リソース情報 | |
ヒト・動物細胞 | HCE-T(RCB2280) |