論文 - 詳細
| RRC ID | 44722 |
|---|---|
| 著者 | Chen DL, Wang ZQ, Ren C, Zeng ZL, Wang DS, Luo HY, Wang F, Qiu MZ, Bai L, Zhang DS, Wang FH, Li YH, Xu RH. |
| タイトル | Abnormal expression of paxillin correlates with tumor progression and poor survival in patients with gastric cancer. |
| ジャーナル | J Transl Med |
| Abstract |
BACKGROUND:Paxillin (PXN) has been found to be aberrantly regulated in various malignancies and involved in tumor growth and invasion. The clinicopathological and prognostic significance of PXN in gastric cancer is still unclear. METHODS:The expression of PXN was determined in paired gastric cancer tissues and adjacent normal tissues by Western blotting and real-time PCR. Immunohistochemistry was performed to detect the expression of PXN in 239 gastric cancer patients. Statistical analysis was applied to investigate the correlation between PXN expression and clinicopathological characteristics and prognosis in patients. Additionally, the effects of PXN on gastric cancer cell proliferation and migration were also evaluated. RESULTS:PXN was up-regulated in gastric cancer tissues and cell lines as compared with adjacent normal tissues and normal gastric epithelial cell line GES-1. Overexpression of PXN was correlated with distant metastasis (P=0.001) and advanced tumor stage (P=0.021) in gastric cancer patients. Patients with high PXN expression tended to have poor prognosis compared with patients with low PXN expression (P<0.001). Multivariate analysis demonstrated that PXN expression was an independent prognostic factor (P=0.020). Moreover, ectopic expression of PXN promotes cell proliferation and migration in AGS cells whereas knockdown of PXN inhibits cell proliferation and migration in SGC7901 cells. CONCLUSIONS:PXN plays an important role in tumor progression and may be used as a potential prognostic indicator in gastric cancer. |
| 巻・号 | 11 |
| ページ | 277 |
| 公開日 | 2013-11-2 |
| DOI | 10.1186/1479-5876-11-277 |
| PII | 1479-5876-11-277 |
| PMID | 24180516 |
| PMC | PMC4228400 |
| MeSH | Adult Aged Base Sequence Blotting, Western Cell Line, Tumor DNA Primers Disease Progression Female Humans Male Middle Aged Paxillin / metabolism* Real-Time Polymerase Chain Reaction Stomach Neoplasms / metabolism* Stomach Neoplasms / pathology Survival Rate* |
| IF | 4.124 |
| 引用数 | 19 |
| WOS 分野 | MEDICINE, RESEARCH & EXPERIMENTAL |
| リソース情報 | |
| ヒト・動物細胞 | HGC-27(RCB0500) MKN28(RCB1000) |