| RRC ID |
44763
|
| 著者 |
Kang J, Jeong MG, Oh S, Jang EJ, Kim HK, Hwang ES.
|
| タイトル |
A FoxO1-dependent, but NRF2-independent induction of heme oxygenase-1 during muscle atrophy.
|
| ジャーナル |
FEBS Lett
|
| Abstract |
Skeletal muscle plays key roles in metabolic homeostasis. Loss of muscle mass, called muscle atrophy exacerbates disease-associated metabolic perturbations. In this study, we characterized the molecular functions and mechanisms underlying regulation of skeletal muscle atrophy induced by denervation. Denervation significantly increased the expression of heme oxygenase-1 (HO-1) and atrogenes in skeletal muscle. Forkhead box protein O1 (FoxO1) drastically increased in atrophied muscle and selectively stimulated HO-1 gene transcription through direct DNA binding. Lack of HO-1 substantially attenuated muscle atrophy, whereas HO-1 overexpression caused muscle damage in vitro and in vivo. Collectively, HO-1 induced by FoxO1 may cause skeletal muscle atrophy.
|
| 巻・号 |
588(1)
|
| ページ |
79-85
|
| 公開日 |
2014-1-3
|
| DOI |
10.1016/j.febslet.2013.11.009
|
| PII |
S0014-5793(13)00843-0
|
| PMID |
24269680
|
| MeSH |
Animals
Cell Line
Denervation
Forkhead Box Protein O1
Forkhead Transcription Factors / genetics
Forkhead Transcription Factors / metabolism*
Gene Expression
Heme Oxygenase-1 / genetics
Heme Oxygenase-1 / metabolism*
Immunoblotting
Immunohistochemistry
Mice
Mice, Inbred C57BL
Mice, Knockout
Models, Genetic
Muscle, Skeletal / innervation
Muscle, Skeletal / metabolism
Muscular Atrophy / genetics
Muscular Atrophy / metabolism*
NF-E2-Related Factor 2 / genetics
NF-E2-Related Factor 2 / metabolism*
Protein Binding
RNA Interference
Reverse Transcriptase Polymerase Chain Reaction
Sciatic Nerve / injuries
Sciatic Nerve / physiopathology
|
| IF |
3.057
|
| 引用数 |
25
|
|
WOS 分野
|
BIOPHYSICS
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
|
