論文 - 詳細
| RRC ID | 44763 |
|---|---|
| 著者 | Kang J, Jeong MG, Oh S, Jang EJ, Kim HK, Hwang ES. |
| タイトル | A FoxO1-dependent, but NRF2-independent induction of heme oxygenase-1 during muscle atrophy. |
| ジャーナル | FEBS Lett |
| Abstract |
Skeletal muscle plays key roles in metabolic homeostasis. Loss of muscle mass, called muscle atrophy exacerbates disease-associated metabolic perturbations. In this study, we characterized the molecular functions and mechanisms underlying regulation of skeletal muscle atrophy induced by denervation. Denervation significantly increased the expression of heme oxygenase-1 (HO-1) and atrogenes in skeletal muscle. Forkhead box protein O1 (FoxO1) drastically increased in atrophied muscle and selectively stimulated HO-1 gene transcription through direct DNA binding. Lack of HO-1 substantially attenuated muscle atrophy, whereas HO-1 overexpression caused muscle damage in vitro and in vivo. Collectively, HO-1 induced by FoxO1 may cause skeletal muscle atrophy. |
| 巻・号 | 588(1) |
| ページ | 79-85 |
| 公開日 | 2014-1-3 |
| DOI | 10.1016/j.febslet.2013.11.009 |
| PII | S0014-5793(13)00843-0 |
| PMID | 24269680 |
| MeSH | Animals Cell Line Denervation Forkhead Box Protein O1 Forkhead Transcription Factors / genetics Forkhead Transcription Factors / metabolism* Gene Expression Heme Oxygenase-1 / genetics Heme Oxygenase-1 / metabolism* Immunoblotting Immunohistochemistry Mice Mice, Inbred C57BL Mice, Knockout Models, Genetic Muscle, Skeletal / innervation Muscle, Skeletal / metabolism Muscular Atrophy / genetics Muscular Atrophy / metabolism* NF-E2-Related Factor 2 / genetics NF-E2-Related Factor 2 / metabolism* Protein Binding RNA Interference Reverse Transcriptase Polymerase Chain Reaction Sciatic Nerve / injuries Sciatic Nerve / physiopathology |
| IF | 3.057 |
| 引用数 | 25 |
| WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | |