論文 - 詳細
| RRC ID | 44776 |
|---|---|
| 著者 | Tatsuta T, Hosono M, Takahashi K, Omoto T, Kariya Y, Sugawara S, Hakomori S, Nitta K. |
| タイトル | Sialic acid-binding lectin (leczyme) induces apoptosis to malignant mesothelioma and exerts synergistic antitumor effects with TRAIL. |
| ジャーナル | Int J Oncol |
| Abstract |
Malignant mesothelioma is a highly aggressive tumor with poor prognosis. An effective drug for treatment of malignant mesothelioma is greatly needed. Sialic acid-binding lectin (SBL) isolated from oocytes of Rana catesbeiana is a multifunctional protein which has lectin activity, ribonuclease activity and antitumor activity, so it could be developed as a new type of anticancer drug. The validity of SBL for treatment of malignant mesothelioma was assessed using three malignant mesotheliomas and a non-malignant mesothlial cell line. Effectiveness of combinatorial treatment of SBL and tumor necrosis factor-related apoptosis inducing ligand (TRAIL) was also elucidated and characterized. SBL induced tumor-selective cytotoxicity that was attributed to induction of apoptosis. Combinatorial treatment of SBL and TRAIL showed synergistic apoptosis-inducing effect. Additional experiments revealed that Bid was the mediating molecule for the synergistic effect in SBL and TRAIL. These results suggested that SBL could be a promising candidate for the therapeutics for malignant mesothelioma. Furthermore, the combinatorial treatment of SBL and TRAIL could be an effective regimen against malignant mesothelioma. |
| 巻・号 | 44(2) |
| ページ | 377-84 |
| 公開日 | 2014-2-1 |
| DOI | 10.3892/ijo.2013.2192 |
| PMID | 24297392 |
| PMC | PMC3898873 |
| MeSH | Amphibian Proteins / pharmacology* Apoptosis / drug effects* BH3 Interacting Domain Death Agonist Protein / metabolism Blotting, Western Cell Proliferation Drug Combinations Drug Synergism* Humans Lectins / pharmacology* Lung Neoplasms / metabolism Lung Neoplasms / pathology* Lung Neoplasms / prevention & control Membrane Potential, Mitochondrial Mesothelioma / metabolism Mesothelioma / pathology* Mesothelioma / prevention & control Mesothelioma, Malignant Mitochondria / metabolism Ribonucleases / pharmacology* TNF-Related Apoptosis-Inducing Ligand / pharmacology* Tumor Cells, Cultured |
| IF | 3.899 |
| 引用数 | 14 |
| WOS 分野 | ONCOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ヒト・動物細胞 | ACC-MESO-1(RCB2292) ACC-MESO-4(RCB2293) |