| RRC ID |
44785
|
| 著者 |
Tamaru T, Hattori M, Ninomiya Y, Kawamura G, Varès G, Honda K, Mishra DP, Wang B, Benjamin I, Sassone-Corsi P, Ozawa T, Takamatsu K.
|
| タイトル |
ROS stress resets circadian clocks to coordinate pro-survival signals.
|
| ジャーナル |
PLoS One
|
| Abstract |
Dysfunction of circadian clocks exacerbates various diseases, in part likely due to impaired stress resistance. It is unclear how circadian clock system responds toward critical stresses, to evoke life-protective adaptation. We identified a reactive oxygen species (ROS), H2O2 -responsive circadian pathway in mammals. Near-lethal doses of ROS-induced critical oxidative stress (cOS) at the branch point of life and death resets circadian clocks, synergistically evoking protective responses for cell survival. The cOS-triggered clock resetting and pro-survival responses are mediated by transcription factor, central clock-regulatory BMAL1 and heat shock stress-responsive (HSR) HSF1. Casein kinase II (CK2) -mediated phosphorylation regulates dimerization and function of BMAL1 and HSF1 to control the cOS-evoked responses. The core cOS-responsive transcriptome includes CK2-regulated crosstalk between the circadian, HSR, NF-kappa-B-mediated anti-apoptotic, and Nrf2-mediated anti-oxidant pathways. This novel circadian-adaptive signaling system likely plays fundamental protective roles in various ROS-inducible disorders, diseases, and death.
|
| 巻・号 |
8(12)
|
| ページ |
e82006
|
| 公開日 |
2013-1-1
|
| DOI |
10.1371/journal.pone.0082006
|
| PII |
PONE-D-13-28829
|
| PMID |
24312621
|
| PMC |
PMC3846904
|
| MeSH |
Animals
Casein Kinase II / metabolism
Cell Survival
Circadian Clocks*
Heat-Shock Response
Mice
NIH 3T3 Cells
Oxidative Stress*
Reactive Oxygen Species / metabolism*
Signal Transduction
Transcriptome
|
| IF |
2.74
|
| 引用数 |
51
|
|
WOS 分野
|
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
NIH-3T3 |
