論文 - 詳細
| RRC ID | 44785 |
|---|---|
| 著者 | Tamaru T, Hattori M, Ninomiya Y, Kawamura G, Varès G, Honda K, Mishra DP, Wang B, Benjamin I, Sassone-Corsi P, Ozawa T, Takamatsu K. |
| タイトル | ROS stress resets circadian clocks to coordinate pro-survival signals. |
| ジャーナル | PLoS One |
| Abstract |
Dysfunction of circadian clocks exacerbates various diseases, in part likely due to impaired stress resistance. It is unclear how circadian clock system responds toward critical stresses, to evoke life-protective adaptation. We identified a reactive oxygen species (ROS), H2O2 -responsive circadian pathway in mammals. Near-lethal doses of ROS-induced critical oxidative stress (cOS) at the branch point of life and death resets circadian clocks, synergistically evoking protective responses for cell survival. The cOS-triggered clock resetting and pro-survival responses are mediated by transcription factor, central clock-regulatory BMAL1 and heat shock stress-responsive (HSR) HSF1. Casein kinase II (CK2) -mediated phosphorylation regulates dimerization and function of BMAL1 and HSF1 to control the cOS-evoked responses. The core cOS-responsive transcriptome includes CK2-regulated crosstalk between the circadian, HSR, NF-kappa-B-mediated anti-apoptotic, and Nrf2-mediated anti-oxidant pathways. This novel circadian-adaptive signaling system likely plays fundamental protective roles in various ROS-inducible disorders, diseases, and death. |
| 巻・号 | 8(12) |
| ページ | e82006 |
| 公開日 | 2013-1-1 |
| DOI | 10.1371/journal.pone.0082006 |
| PII | PONE-D-13-28829 |
| PMID | 24312621 |
| PMC | PMC3846904 |
| MeSH | Animals Casein Kinase II / metabolism Cell Survival Circadian Clocks* Heat-Shock Response Mice NIH 3T3 Cells Oxidative Stress* Reactive Oxygen Species / metabolism* Signal Transduction Transcriptome |
| IF | 2.74 |
| 引用数 | 51 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 14 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | NIH-3T3 |