| RRC ID |
44813
|
| 著者 |
Tsutsumi T, Ishihara A, Yamamoto A, Asaji H, Yamakawa S, Tokumura A.
|
| タイトル |
The potential protective role of lysophospholipid mediators in nephrotoxicity induced by chronically exposed cadmium.
|
| ジャーナル |
Food Chem Toxicol
|
| Abstract |
Cadmium is a hazardous metal whose chronic exposure induces renal failure due to fibrosis, but the mechanisms are not well known. In this study we analyzed the molecular species of lysophosphatidic acid (LPA) and related phospholipids, together with their metabolic enzyme activity, in plasma from Wistar rats exposed up to 300ppm Cd(2+) in drinking water for 114days. Exposure of 300ppm Cd(2+) for 114days enhanced autotoxin (ATX)/lysophospholipase D activity, but significantly lowered the total levels of LPA and lysophosphatidylethanolamine. Interestingly, the total level of sphingosine-1-phosphate (S1P) was elevated dose-dependently by Cd(2+). Cultured rat kidney-derived interstitial fibroblast cells, NRK49F cells and proximal epithelial cells, NRK52E cells, were both responsive to the protective action of LPA or S1P against Cd(2+) toxicity. The former cell expresses ATX RNA. In conclusion, the elevation of LPA-producing enzyme activity and S1P concentrations in plasma after exposure of rats to Cd(2+) would protect from the renal toxicity of Cd(2+).
|
| 巻・号 |
65
|
| ページ |
52-62
|
| 公開日 |
2014-3-1
|
| DOI |
10.1016/j.fct.2013.12.019
|
| PII |
S0278-6915(13)00841-7
|
| PMID |
24361405
|
| MeSH |
Adipose Tissue / drug effects
Animals
Base Sequence
Body Weight / drug effects
Cadmium / toxicity*
Chromatography, Liquid
DNA Primers
Kidney / drug effects*
Lysophospholipids / physiology*
Male
Organ Size / drug effects
Rats
Rats, Wistar
Reverse Transcriptase Polymerase Chain Reaction
Tandem Mass Spectrometry
|
| IF |
4.679
|
| 引用数 |
9
|
|
WOS 分野
|
FOOD SCIENCE & TECHNOLOGY
TOXICOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
|
