| RRC ID |
44820
|
| Author |
Wang H, Wang B, Liao Q, An H, Li W, Jin X, Cui S, Zhao L.
|
| Title |
Overexpression of RhoGDI, a novel predictor of distant metastasis, promotes cell proliferation and migration in hepatocellular carcinoma.
|
| Journal |
FEBS Lett
|
| Abstract |
RhoGDI (Rho GDP-dissociation inhibitor alpha, or RhoGDIα) was identified as a regulator of Rho GTPases, but its role in cancer remains controversial. In this study, increased expression of RhoGDI was detected in hepatocellular carcinoma (HCC) cell lines and tissues with highly metastatic potential. RhoGDI overexpression correlated with postoperative distant metastasis. Enforced expression of RhoGDI in HCC cells significantly enhanced cell proliferation and migration. Conversely, knockdown of RhoGDI caused an inhibition of the aggressive phenotypes of HCC cells. Furthermore, RhoGDI up-regulated Rho, but not Rac, and enhanced PI3K/AKT and MAPK pathway activity. Our findings suggest that RhoGDI overexpression is a predictor of distant metastasis and plays an important role in the progression of HCC.
|
| Volume |
588(3)
|
| Pages |
503-8
|
| Published |
2014-1-31
|
| DOI |
10.1016/j.febslet.2013.12.016
|
| PII |
S0014-5793(13)00924-1
|
| PMID |
24374343
|
| MeSH |
Carcinoma, Hepatocellular / genetics*
Carcinoma, Hepatocellular / metabolism
Carcinoma, Hepatocellular / pathology
Cell Line, Tumor
Cell Movement / genetics
Cell Proliferation*
Gene Expression Regulation, Neoplastic
Gene Knockdown Techniques
Humans
Liver Neoplasms / genetics*
Liver Neoplasms / metabolism
Liver Neoplasms / pathology
Neoplasm Metastasis / genetics
Prognosis
Signal Transduction
rac GTP-Binding Proteins / metabolism
rho GTP-Binding Proteins / metabolism
rho Guanine Nucleotide Dissociation Inhibitor alpha / genetics*
rho Guanine Nucleotide Dissociation Inhibitor alpha / metabolism
rho-Associated Kinases / metabolism
|
| IF |
3.057
|
| Times Cited |
19
|
|
WOS Category
|
BIOPHYSICS
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
|
| Resource |
| Human and Animal Cells |
HuH-7(RCB1366) |
