RRC ID 44826
Author Shakya B, Yadav PN, Ueda JY, Awale S.
Title Discovery of 2-pyridineformamide thiosemicarbazones as potent antiausterity agents.
Journal Bioorg. Med. Chem. Lett.
Abstract Series of 2-pyridineformamide thiosemicarbazones were synthesized. Their preferential cytotoxicity in nutrient deprived medium (NDM) was evaluated using PANC-1 human pancreatic cancer cells by employing an antiausterity strategy. 2-Pyridineformamide thiosemicarbazones induced apoptosis and exhibited preferential cytotoxic activity toward PANC-1 cells in NDM, with potencies in the submicromolar range. These compounds are potential candidates for the development of therapeutics against pancreatic cancer.
Volume 24(2)
Pages 458-61
Published 2014-1-15
DOI 10.1016/j.bmcl.2013.12.044
PII S0960-894X(13)01416-9
PMID 24380769
MeSH Antineoplastic Agents / chemistry* Antineoplastic Agents / therapeutic use Cell Line, Tumor Dose-Response Relationship, Drug Drug Screening Assays, Antitumor / methods Formamides / chemistry* Formamides / therapeutic use Humans Pancreatic Neoplasms / drug therapy* Pancreatic Neoplasms / pathology Pyridines / chemistry* Pyridines / therapeutic use Thiosemicarbazones / chemistry* Thiosemicarbazones / therapeutic use
IF 2.448
Times Cited 13
WOS Category CHEMISTRY, MEDICINAL CHEMISTRY, ORGANIC
Resource
Human and Animal Cells