論文 - 詳細
| RRC ID | 44883 |
|---|---|
| 著者 | Yoshizawa K, Taguchi T. |
| タイトル | Enhanced bonding strength of hydrophobically modified gelatin films on wet blood vessels. |
| ジャーナル | Int J Mol Sci |
| Abstract |
The bonding behavior between hydrophobically modified alkaline-treated gelatin (hm-AlGltn) films and porcine blood vessels was evaluated under wet conditions. Hexanoyl (Hx: C6), decanoyl (Dec: C10), and stearyl (Ste: C18) chlorides were introduced into the amino groups of AlGltn to obtain HxAlGltn, DecAlGltn, and SteAlGltn, respectively, with various modification percentages. The hm-AlGltn was fabricated into films and thermally crosslinked to obtain water-insoluble films (t-hm-AlGltn). The 42% modified t-HxAlGltn (t-42HxAlGltn) possessed higher wettability than the 38% modified t-DecAlGltn (t-38DecAlGltn) and the 44% modified t-SteAlGltn (t-44SteAlGltn) films, and the t-42HxAlGltn film showed a high bonding strength with the blood vessel compared with all the hm-AlGltn films. Histological observations indicated that t-42HxAlGltn and t-38DecAlGltn remained on the blood vessel even after the bonding strength measurements. From cell culture experiments, the t-42HxAlGltn films showed significant cell adhesion compared to other films. These findings indicate that the Hx group easily interpenetrated the surface of blood vessels and effectively enhanced the bonding strength between the films and the tissue. |
| 巻・号 | 15(2) |
| ページ | 2142-56 |
| 公開日 | 2014-1-29 |
| DOI | 10.3390/ijms15022142 |
| PII | ijms15022142 |
| PMID | 24481063 |
| PMC | PMC3958842 |
| MeSH | Animals Biocompatible Materials Blood Vessels* Cell Adhesion Cell Line Gelatin / chemical synthesis Gelatin / chemistry* Hydrophobic and Hydrophilic Interactions Materials Testing Mice Surface Properties Swine Wettability |
| IF | 4.556 |
| 引用数 | 10 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CHEMISTRY, MULTIDISCIPLINARY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | L929 |