RRC ID 44915
Author Balasubramanian S, Girija AR, Nagaoka Y, Iwai S, Suzuki M, Kizhikkilot V, Yoshida Y, Maekawa T, Nair SD.
Title Curcumin and 5-fluorouracil-loaded, folate- and transferrin-decorated polymeric magnetic nanoformulation: a synergistic cancer therapeutic approach, accelerated by magnetic hyperthermia.
Journal Int J Nanomedicine
Abstract The efficient targeting and therapeutic efficacy of a combination of drugs (curcumin and 5-Fluorouracil [5FU]) and magnetic nanoparticles encapsulated poly(D,L-lactic-co-glycolic acid) nanoparticles, functionalized with two cancer-specific ligands are discussed in our work. This multifunctional, highly specific nanoconjugate resulted in the superior uptake of nanoparticles by cancer cells. Upon magnetic hyperthermia, we could harness the advantages of incorporating magnetic nanoparticles that synergistically acted with the drugs to destroy cancer cells within a very short period of time. The remarkable multimodal efficacy attained by this therapeutic nanoformulation offers the potential for targeting, imaging, and treatment of cancer within a short period of time (120 minutes) by initiating early and late apoptosis.
Volume 9
Pages 437-59
Published 2014
DOI 10.2147/IJN.S49882
PII ijn-9-437
PMID 24531392
PMC PMC3891567
MeSH Animals Antineoplastic Agents / administration & dosage Apoptosis / drug effects Cell Line Combined Modality Therapy Curcumin / administration & dosage* Drug Carriers / chemistry Fluorouracil / administration & dosage* Folic Acid / chemistry Humans Hyperthermia, Induced / methods Lactic Acid / chemistry MCF-7 Cells Magnetite Nanoparticles / administration & dosage* Magnetite Nanoparticles / chemistry Mice Nanoconjugates / administration & dosage Nanoconjugates / chemistry Nanomedicine Nanotechnology Neoplasms / drug therapy Neoplasms / pathology Neoplasms / therapy* Polyglycolic Acid / chemistry Polylactic Acid-Polyglycolic Acid Copolymer Transferrin / chemistry
IF 4.471
Human and Animal Cells