論文 - 詳細
| RRC ID | 44915 |
|---|---|
| 著者 | Balasubramanian S, Girija AR, Nagaoka Y, Iwai S, Suzuki M, Kizhikkilot V, Yoshida Y, Maekawa T, Nair SD. |
| タイトル | Curcumin and 5-fluorouracil-loaded, folate- and transferrin-decorated polymeric magnetic nanoformulation: a synergistic cancer therapeutic approach, accelerated by magnetic hyperthermia. |
| ジャーナル | Int J Nanomedicine |
| Abstract |
The efficient targeting and therapeutic efficacy of a combination of drugs (curcumin and 5-Fluorouracil [5FU]) and magnetic nanoparticles encapsulated poly(D,L-lactic-co-glycolic acid) nanoparticles, functionalized with two cancer-specific ligands are discussed in our work. This multifunctional, highly specific nanoconjugate resulted in the superior uptake of nanoparticles by cancer cells. Upon magnetic hyperthermia, we could harness the advantages of incorporating magnetic nanoparticles that synergistically acted with the drugs to destroy cancer cells within a very short period of time. The remarkable multimodal efficacy attained by this therapeutic nanoformulation offers the potential for targeting, imaging, and treatment of cancer within a short period of time (120 minutes) by initiating early and late apoptosis. |
| 巻・号 | 9 |
| ページ | 437-59 |
| 公開日 | 2014-1-1 |
| DOI | 10.2147/IJN.S49882 |
| PII | ijn-9-437 |
| PMID | 24531392 |
| PMC | PMC3891567 |
| MeSH | Animals Antineoplastic Agents / administration & dosage Apoptosis / drug effects Cell Line Combined Modality Therapy Curcumin / administration & dosage* Drug Carriers / chemistry Fluorouracil / administration & dosage* Folic Acid / chemistry Humans Hyperthermia, Induced / methods Lactic Acid / chemistry MCF-7 Cells Magnetite Nanoparticles / administration & dosage* Magnetite Nanoparticles / chemistry Mice Nanoconjugates / administration & dosage Nanoconjugates / chemistry Nanomedicine Nanotechnology Neoplasms / drug therapy Neoplasms / pathology Neoplasms / therapy* Polyglycolic Acid / chemistry Polylactic Acid-Polyglycolic Acid Copolymer Transferrin / chemistry |
| IF | 5.115 |
| 引用数 | 73 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | MCF7(RCB1904) L929 |