RRC ID 44952
Author Zhang YA, Zhu JM, Yin J, Tang WQ, Guo YM, Shen XZ, Liu TT.
Title High expression of neuro-oncological ventral antigen 1 correlates with poor prognosis in hepatocellular carcinoma.
Journal PLoS ONE
Abstract Neuro-oncological ventral antigen 1 (Nova1) is a neuron-specific RNA-binding protein in human paraneoplastic opsoclonus-myoclonus ataxia accompanying with malignant tumors, but its role in hepatocellular carcinoma (HCC) remains elusive. In this study, we found that overexpressed intratumoral Nova1 was associated with poor survival rate and increased recurrence rate of HCC, especially early recurrence, and was an independent prognostic factor for overall survival rate and tumor recurrence. HCC cell lines over-expressing Nova1 exhibited greater potentials in cell proliferation, invasion and migration, while knockdown of Nova1 had the opposite effects. All these findings indicate that Nova1 may act as a prognostic marker for poor outcome and high recurrence in HCC.
Volume 9(3)
Pages e90955
Published 2014
DOI 10.1371/journal.pone.0090955
PII PONE-D-13-44416
PMID 24608171
PMC PMC3946567
MeSH Biomarkers, Tumor / genetics* Biomarkers, Tumor / metabolism Carcinoma, Hepatocellular / genetics* Carcinoma, Hepatocellular / mortality Carcinoma, Hepatocellular / pathology Carcinoma, Hepatocellular / surgery Cell Line, Tumor Cell Movement Cell Proliferation Female Follow-Up Studies Gene Expression Humans Liver Neoplasms / genetics* Liver Neoplasms / metabolism Liver Neoplasms / pathology Middle Aged Neoplasm Recurrence, Local / genetics* Neoplasm Recurrence, Local / mortality Neoplasm Recurrence, Local / pathology Neoplasm Recurrence, Local / surgery Prognosis RNA, Small Interfering / genetics RNA, Small Interfering / metabolism RNA-Binding Proteins / antagonists & inhibitors RNA-Binding Proteins / genetics* RNA-Binding Proteins / metabolism Survival Analysis
IF 2.776
Human and Animal Cells