RRC ID |
44952
|
著者 |
Zhang YA, Zhu JM, Yin J, Tang WQ, Guo YM, Shen XZ, Liu TT.
|
タイトル |
High expression of neuro-oncological ventral antigen 1 correlates with poor prognosis in hepatocellular carcinoma.
|
ジャーナル |
PLoS One
|
Abstract |
Neuro-oncological ventral antigen 1 (Nova1) is a neuron-specific RNA-binding protein in human paraneoplastic opsoclonus-myoclonus ataxia accompanying with malignant tumors, but its role in hepatocellular carcinoma (HCC) remains elusive. In this study, we found that overexpressed intratumoral Nova1 was associated with poor survival rate and increased recurrence rate of HCC, especially early recurrence, and was an independent prognostic factor for overall survival rate and tumor recurrence. HCC cell lines over-expressing Nova1 exhibited greater potentials in cell proliferation, invasion and migration, while knockdown of Nova1 had the opposite effects. All these findings indicate that Nova1 may act as a prognostic marker for poor outcome and high recurrence in HCC.
|
巻・号 |
9(3)
|
ページ |
e90955
|
公開日 |
2014-1-1
|
DOI |
10.1371/journal.pone.0090955
|
PII |
PONE-D-13-44416
|
PMID |
24608171
|
PMC |
PMC3946567
|
MeSH |
Biomarkers, Tumor / genetics*
Biomarkers, Tumor / metabolism
Carcinoma, Hepatocellular / genetics*
Carcinoma, Hepatocellular / mortality
Carcinoma, Hepatocellular / pathology
Carcinoma, Hepatocellular / surgery
Cell Line, Tumor
Cell Movement
Cell Proliferation
Female
Follow-Up Studies
Gene Expression
Humans
Liver Neoplasms / genetics*
Liver Neoplasms / metabolism
Liver Neoplasms / pathology
Middle Aged
Neoplasm Recurrence, Local / genetics*
Neoplasm Recurrence, Local / mortality
Neoplasm Recurrence, Local / pathology
Neoplasm Recurrence, Local / surgery
Neuro-Oncological Ventral Antigen
Prognosis
RNA, Small Interfering / genetics
RNA, Small Interfering / metabolism
RNA-Binding Proteins / antagonists & inhibitors
RNA-Binding Proteins / genetics*
RNA-Binding Proteins / metabolism
Survival Analysis
|
IF |
2.74
|
引用数 |
1
|
リソース情報 |
ヒト・動物細胞 |
HuH-7 |