論文 - 詳細
| RRC ID | 44988 |
|---|---|
| 著者 | Andersson R, Gebhard C, Miguel-Escalada I, Hoof I, Bornholdt J, Boyd M, Chen Y, Zhao X, Schmidl C, Suzuki T, Ntini E, Arner E, Valen E, Li K, Schwarzfischer L, Glatz D, Raithel J, Lilje B, Rapin N, Bagger FO, Jørgensen M, Andersen PR, Bertin N, Rackham O, Burroughs AM, Baillie JK, Ishizu Y, Shimizu Y, Furuhata E, Maeda S, Negishi Y, Mungall CJ, Meehan TF, Lassmann T, Itoh M, Kawaji H, Kondo N, Kawai J, Lennartsson A, Daub CO, Heutink P, Hume DA, Jensen TH, Suzuki H, Hayashizaki Y, Müller F, Forrest ARR, Carninci P, Rehli M, Sandelin A. |
| タイトル | An atlas of active enhancers across human cell types and tissues. |
| ジャーナル | Nature |
| Abstract |
Enhancers control the correct temporal and cell-type-specific activation of gene expression in multicellular eukaryotes. Knowing their properties, regulatory activity and targets is crucial to understand the regulation of differentiation and homeostasis. Here we use the FANTOM5 panel of samples, covering the majority of human tissues and cell types, to produce an atlas of active, in vivo-transcribed enhancers. We show that enhancers share properties with CpG-poor messenger RNA promoters but produce bidirectional, exosome-sensitive, relatively short unspliced RNAs, the generation of which is strongly related to enhancer activity. The atlas is used to compare regulatory programs between different cells at unprecedented depth, to identify disease-associated regulatory single nucleotide polymorphisms, and to classify cell-type-specific and ubiquitous enhancers. We further explore the utility of enhancer redundancy, which explains gene expression strength rather than expression patterns. The online FANTOM5 enhancer atlas represents a unique resource for studies on cell-type-specific enhancers and gene regulation. |
| 巻・号 | 507(7493) |
| ページ | 455-461 |
| 公開日 | 2014-3-27 |
| DOI | 10.1038/nature12787 |
| PMID | 24670763 |
| PMC | PMC5215096 |
| MeSH | Atlases as Topic* Cell Line Cells, Cultured Cluster Analysis Enhancer Elements, Genetic / genetics* Gene Expression Regulation / genetics* Genetic Predisposition to Disease / genetics HeLa Cells Humans Molecular Sequence Annotation* Organ Specificity* Polymorphism, Single Nucleotide / genetics Promoter Regions, Genetic / genetics RNA, Messenger / biosynthesis RNA, Messenger / genetics Transcription Initiation Site Transcription Initiation, Genetic |
| IF | 42.779 |
| 引用数 | 1042 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 206 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 6.0 |
| リソース情報 | |
| ヒト・動物細胞 | Hep G2 |