RRC ID 4499
Author Ookubo A, Hirasawa T, Yoshikawa K, Nagahisa K, Furusawa C, Shimizu H.
Title Improvement of L-lactate production by CYB2 gene disruption in a recombinant Saccharomyces cerevisiae strain under low pH condition.
Journal Biosci. Biotechnol. Biochem.
Abstract Using a DNA microarray, we found that expression of the genes related to lactate metabolism was upregulated in a lactate-producing recombinant Saccharomyces cerevisiae strain. Disruption of the CYB2 gene encoding L-lactate dehydrogenase improved the L-lactate production by S. cerevisiae under low pH condition.
Volume 72(11)
Pages 3063-6
Published 2008-11
DOI 10.1271/bbb.80493
PII JST.JSTAGE/bbb/80493
PMID 18997405
MeSH Genetic Engineering* Humans Hydrogen-Ion Concentration L-Lactate Dehydrogenase / genetics* L-Lactate Dehydrogenase / metabolism Lactic Acid / biosynthesis* Saccharomyces cerevisiae / genetics* Saccharomyces cerevisiae / metabolism*
IF 1.297
Times Cited 8
WOS Category FOOD SCIENCE & TECHNOLOGY CHEMISTRY, APPLIED BIOTECHNOLOGY & APPLIED MICROBIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY
Resource
Yeast BYP1463(=pUG6)