| RRC ID |
44
|
| Author |
Inoue S, Tahara K, Shimizu H, Yoshino H, Suzuki C, Kaneko T, Hakamata Y, Takahashi M, Murakami T, Kaneko M, Kobayashi E.
|
| Title |
Rat liver transplantation for total vascular reconstruction, using a suture method.
|
| Journal |
Microsurgery
|
| Abstract |
We developed a novel protocol for rat orthotopic liver transplantation (OLT), using a suture method to establish hepatic artery flow. After determining that early inferior vena cava (IVC) unclamping maintained better circulation compared with the portal vein (PV) using porto-systemic shunted recipients, we developed a rat OLT model with total vascular reconstruction using a suture method. After connecting the suprahepatic IVC, the infrahepatic IVC was anastomosed, using a running suture method. IVC circulation was established immediately. The PV was anastomosed without intestinal congestion, using porto-systemic shunted recipients. The aortic conduit, including the donor celiac and hepatic artery, was anastomosed to the recipient abdominal aorta end-to-side. Eight of 11 OLT cases (72.7%) survived indefinitely. Biliary connection was achieved using a one-stent method. Three cases died 3-5 days postoperatively. Hepatic angiography showed good patency. The graft liver was histologically normal in long-surviving rats.
|
| Volume |
23(5)
|
| Pages |
470-5
|
| Published |
2003-1-1
|
| DOI |
10.1002/micr.10168
|
| PMID |
14558005
|
| MeSH |
Animals
Aorta / surgery
Celiac Artery / surgery
Hemodynamics / physiology
Hepatic Artery / surgery
Liver Transplantation / methods*
Models, Animal
Portal Vein / surgery
Rats
Rats, Inbred Lew
Suture Techniques*
Vascular Surgical Procedures / methods*
Vena Cava, Inferior / surgery
|
| IF |
1.996
|
| Times Cited |
16
|
|
WOS Category
|
SURGERY
|
| Resource |
| Rats |
|
