| RRC ID |
45013
|
| Author |
Zhao W, Zhang Y, Liu D, Zhong L, He Q, Zhao Y.
|
| Title |
Abnormal expression of CD66a promotes proliferation and inhibits apoptosis of human leukemic B cells in vitro.
|
| Journal |
Leuk Lymphoma
|
| Abstract |
The aberrant expression of myeloid antigen CD66 on acute B-lymphoblastic leukemia (B-ALL) cells is a well-documented phenomenon. CD66a is a major subtype of the CD66 family which plays a dual role in different cancers, and the contradictory effect may depend on the isoform ratio of CD66a-4L to CD66a-4S. Although the abnormal expression of CD66a on leukemic B-cells has been reported widely, little is known about the biological function of this aberrant expression. In this study, we showed that inhibition of CD66a in human B-ALL cell lines reduced the cellular proliferative rate and increased the percentage of cellular apoptosis, and the ratio of CD66a-4L to CD66a-4S in leukemic B cells is much higher than that in granulocytes. In addition, alteration of the L:S ratio by silencing and overexpressing the L isoform in B-ALL cell lines confirmed that a high L:S ratio of CD66a in leukemic B cells promotes proliferation and inhibits FasL-induced apoptosis.
|
| Volume |
56(1)
|
| Pages |
202-10
|
| Published |
2015-1-1
|
| DOI |
10.3109/10428194.2014.913287
|
| PMID |
24716460
|
| MeSH |
Antigens, CD / genetics*
Antigens, CD / metabolism
Apoptosis / genetics*
Caspases / metabolism
Cell Adhesion Molecules / genetics*
Cell Adhesion Molecules / metabolism
Cell Line, Tumor
Cell Membrane / metabolism
Cell Proliferation
Fas Ligand Protein / genetics
Fas Ligand Protein / metabolism
Gene Expression*
Granulocytes / metabolism
Humans
Leukemia, B-Cell / genetics*
Leukemia, B-Cell / metabolism
Protein Isoforms
RNA Interference
RNA, Small Interfering / genetics
|
| IF |
2.969
|
| Times Cited |
2
|
|
WOS Category
|
HEMATOLOGY
ONCOLOGY
|
| Resource |
| Human and Animal Cells |
BALL-1 |
