Reference - Detail
| RRC ID | 45030 |
|---|---|
| Author | Yang XQ, Xu YF, Guo S, Liu Y, Ning SL, Lu XF, Yang H, Chen YX. |
| Title | Clinical significance of nerve growth factor and tropomyosin-receptor-kinase signaling pathway in intrahepatic cholangiocarcinoma. |
| Journal | World J Gastroenterol |
| Abstract |
AIM:To investigate the correlation between nerve growth factor-tropomyosin-receptor-kinase (NGF-TrkA) signaling pathway and prognosis in intrahepatic cholangiocarcinoma (IHCC). METHODS:NGF and TrkA expression in 83 samples of IHCC was assessed by immunohistochemistry. Correlations between NGF-TrkA expression and clinicopathological features were analyzed by χ² test. Moreover, we evaluated the association between NGF-TrkA and overall survival by univariate and multivariate analysis. With experiments in vitro, we investigated the crucial role of NGF-TrkA on proliferation and invasion of IHCC cells with recombinant NGF-β stimulation. RESULTS:We found that NGF and TrkA expression was significantly related with differentiation (P = 0.024) and intraneural invasion (P = 0.003), respectively. Additionally, double higher expression of NGF and TrkA was identified as an independent prognostic factor in IHCC (P = 0.003). Moreover, we demonstrated that NGF-TrkA signaling pathway can promote IHCC proliferation and invasion. CONCLUSION:NGF-TrkA double higher expression is an independent prognostic factor in IHCC. NGF-TrkA pathway can promote IHCC progression, indicating that NGF-TrkA may become a potential drug target. |
| Volume | 20(14) |
| Pages | 4076-84 |
| Published | 2014-4-14 |
| DOI | 10.3748/wjg.v20.i14.4076 |
| PMID | 24744599 |
| PMC | PMC3983466 |
| MeSH | Aged Bile Duct Neoplasms / metabolism* Bile Ducts, Intrahepatic / metabolism* Cell Line, Tumor Cell Proliferation Cholangiocarcinoma / metabolism* Female Gene Expression Regulation, Neoplastic* Humans Immunohistochemistry Kaplan-Meier Estimate Male Middle Aged Multivariate Analysis Neoplasm Invasiveness Neoplasm Metastasis Neoplasm Staging Nerve Growth Factor / metabolism* Prognosis Receptor, trkA / metabolism* Signal Transduction Treatment Outcome |
| IF | 3.665 |
| Times Cited | 27 |
| WOS Category | GASTROENTEROLOGY & HEPATOLOGY |
| Resource | |
| Human and Animal Cells | HuCCT1(RCB1960) |