| RRC ID |
45066
|
| Author |
Takei T, Kitazono J, Tanaka S, Nishimata H, Yoshida M.
|
| Title |
Necrotic regions are absent in fiber-shaped cell aggregates, approximately 100 μm in diameter.
|
| Journal |
Artif Cells Nanomed Biotechnol
|
| Abstract |
Microscopic, fiber-shaped cell aggregates, have been used as building blocks for fabricating macroscopic three-dimensional tissue architectures, in the field of tissue engineering. In this study, we examined the occurrence of necrotic regions in the most widely used, fiber-shaped cell aggregates, approximately 100 μm in diameter. Alginate hydrogel hollow microfibers were used as templates for the cell aggregates. We demonstrated negligible necrotic region formation occurred in the cell aggregates formed in the hollow microfibers. Furthermore, we improved on previously-reported methods for preparing the hollow microfibers to avoid common microfiber tangling during the fiber preparation process.
|
| Volume |
44(1)
|
| Pages |
62-5
|
| Published |
2016-1-1
|
| DOI |
10.3109/21691401.2014.909824
|
| PMID |
24813225
|
| MeSH |
Alginates / chemistry*
Cell Aggregation
Glucuronic Acid / chemistry
Hep G2 Cells
Hexuronic Acids / chemistry
Humans
Hydrogels / chemistry*
Necrosis / prevention & control
Tissue Engineering
|
| IF |
3.343
|
| Times Cited |
3
|
|
WOS Category
|
ENGINEERING, BIOMEDICAL
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
MATERIALS SCIENCE, BIOMATERIALS
|
| Resource |
| Human and Animal Cells |
Hep G2(RCB1648) |
