論文 - 詳細
| RRC ID | 45081 |
|---|---|
| 著者 | Przybyl J, Sciot R, Wozniak A, Schöffski P, Vanspauwen V, Samson I, Siedlecki JA, Rutkowski P, Debiec-Rychter M. |
| タイトル | Metastatic potential is determined early in synovial sarcoma development and reflected by tumor molecular features. |
| ジャーナル | Int J Biochem Cell Biol |
| Abstract |
INTRODUCTION:Synovial sarcoma (SynSa) is an aggressive mesenchymal tumor, comprising approximately 10% of all soft tissue sarcomas. Over half of SynSa patients develop metastasis or local recurrence, but the underlying molecular mechanisms of the aggressive clinical behavior remain poorly characterized. MATERIALS AND METHODS:Sixty-four frozen tumor specimens from 54 SynSa patients were subjected to array comparative genomic hybridization (aCGH) and gene expression profiling. The examined set of tumor specimens included 16 primary tumors from untreated patients who did not develop metastasis/local recurrence (SynSa1 group), 26 primary tumors from untreated patients who developed metastases or local recurrence during follow-up (SynSa2 group), and 22 metachronous metastatic/recurrent SynSa tumors (SynSa3 group). RESULTS:AURKA and KIF18A, which play important roles in various mitotic events, were the two most up-regulated genes in SynSa2 and SynSa3 groups compared to the SynSa1 group. Expression profiles of SynSa2 and SynSa3 tumors did not show any significant differences. Analysis of genomic index (GI) based on aCGH profiles demonstrated that the SynSa1 group consisted of tumors with significantly less complex genomes compared to SynSa2 and SynSa3 groups. There was no significant difference in genome complexity between SynSa2 and SynSa3 tumors. CONCLUSIONS:Primary SynSa tumors from patients who develop metastases or local recurrence share common molecular features with metastatic/recurrent tumors. Presented data suggest that the aggressive clinical SynSa behavior is determined early in tumorigenesis and might be related to impaired regulation of mitotic mechanisms. This article is part of a Directed Issue entitled: Rare Cancers. |
| 巻・号 | 53 |
| ページ | 505-13 |
| 公開日 | 2014-8-1 |
| DOI | 10.1016/j.biocel.2014.05.006 |
| PII | S1357-2725(14)00164-2 |
| PMID | 24842110 |
| MeSH | Adolescent Adult Aged Aged, 80 and over Aurora Kinase A / biosynthesis Aurora Kinase A / genetics Child Child, Preschool Comparative Genomic Hybridization Female Gene Expression Regulation, Neoplastic Humans Karyotype Kinesins / biosynthesis Kinesins / genetics Male Middle Aged Neoplasm Metastasis / genetics Neoplasm Metastasis / pathology Neoplasm Proteins / biosynthesis* Neoplasm Proteins / genetics Neoplasm Recurrence, Local / genetics* Neoplasm Recurrence, Local / pathology Pathology, Molecular Prognosis Sarcoma / genetics* Sarcoma / pathology Sarcoma, Synovial / genetics* Sarcoma, Synovial / pathology |
| IF | 3.673 |
| 引用数 | 25 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | HS-SY-II(RCB2231) |