RRC ID |
45125
|
著者 |
Li Z, Xu L, Tang N, Xu Y, Ye X, Shen S, Niu X, Lu S, Chen Z.
|
タイトル |
The polycomb group protein EZH2 inhibits lung cancer cell growth by repressing the transcription factor Nrf2.
|
ジャーナル |
FEBS Lett
|
Abstract |
EZH2 is a key component of the polycomb PRC2 complex and functions as a histone H3 Lys27 (H3K27) trimethyltransferase. Here we show that EZH2 is down-regulated in human non-small cell lung cancer and low EZH2 expression predicts poor survival. Further we demonstrate that EZH2 inhibits lung cancer cell proliferation and colony formation in vitro and growth in vivo. We found that EZH2 binds to the promoter of Nrf2, where it increases H3K27me3 and represses Nrf2 expression. Finally, Nrf2 seems to be essential for the hyper proliferation of lung cancer cells in the absence of EZH2.
|
巻・号 |
588(17)
|
ページ |
3000-7
|
公開日 |
2014-8-25
|
DOI |
10.1016/j.febslet.2014.05.057
|
PII |
S0014-5793(14)00462-1
|
PMID |
24928441
|
MeSH |
Carcinoma, Non-Small-Cell Lung / genetics*
Carcinoma, Non-Small-Cell Lung / pathology*
Cell Line, Tumor
Cell Proliferation
Disease Progression
Enhancer of Zeste Homolog 2 Protein
Epigenesis, Genetic*
Female
Histones / chemistry
Histones / metabolism
Humans
Lung Neoplasms / genetics*
Lung Neoplasms / pathology*
Lysine / metabolism
Male
Methylation
Middle Aged
NF-E2-Related Factor 2 / genetics*
Polycomb Repressive Complex 2 / metabolism*
Survival Analysis
|
IF |
3.057
|
引用数 |
19
|
WOS 分野
|
BIOPHYSICS
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
|
リソース情報 |
ヒト・動物細胞 |
A459 |