RRC ID 45125
著者 Li Z, Xu L, Tang N, Xu Y, Ye X, Shen S, Niu X, Lu S, Chen Z.
タイトル The polycomb group protein EZH2 inhibits lung cancer cell growth by repressing the transcription factor Nrf2.
ジャーナル FEBS Lett
Abstract EZH2 is a key component of the polycomb PRC2 complex and functions as a histone H3 Lys27 (H3K27) trimethyltransferase. Here we show that EZH2 is down-regulated in human non-small cell lung cancer and low EZH2 expression predicts poor survival. Further we demonstrate that EZH2 inhibits lung cancer cell proliferation and colony formation in vitro and growth in vivo. We found that EZH2 binds to the promoter of Nrf2, where it increases H3K27me3 and represses Nrf2 expression. Finally, Nrf2 seems to be essential for the hyper proliferation of lung cancer cells in the absence of EZH2.
巻・号 588(17)
ページ 3000-7
公開日 2014-8-25
DOI 10.1016/j.febslet.2014.05.057
PII S0014-5793(14)00462-1
PMID 24928441
MeSH Carcinoma, Non-Small-Cell Lung / genetics* Carcinoma, Non-Small-Cell Lung / pathology* Cell Line, Tumor Cell Proliferation Disease Progression Enhancer of Zeste Homolog 2 Protein Epigenesis, Genetic* Female Histones / chemistry Histones / metabolism Humans Lung Neoplasms / genetics* Lung Neoplasms / pathology* Lysine / metabolism Male Methylation Middle Aged NF-E2-Related Factor 2 / genetics* Polycomb Repressive Complex 2 / metabolism* Survival Analysis
IF 3.057
引用数 19
WOS 分野 BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY
リソース情報
ヒト・動物細胞 A459