| RRC ID |
45148
|
| 著者 |
Okudela K, Tateishi Y, Umeda S, Mitsui H, Suzuki T, Saito Y, Woo T, Tajiri M, Masuda M, Miyagi Y, Ohashi K.
|
| タイトル |
Allelic imbalance in the miR-31 host gene locus in lung cancer--its potential role in carcinogenesis.
|
| ジャーナル |
PLoS One
|
| Abstract |
Small non-protein coding RNA, microRNA (miR), which regulate messenger RNA levels, have recently been identified, and may play important roles in the pathogenesis of various diseases. The present study focused on miR-31 and investigated its potential involvement in lung carcinogenesis. The expression of miR-31 was altered in lung cancer cells through either the amplification or loss of the host gene locus. The strong expression of miR-31 in large cell carcinomas was attributed to the gene amplification. Meanwhile, the loss of miR-31 expression was more frequently observed in aggressive adenocarcinomas. Thus, miR-31 may play a pleiotropic role in the development of lung cancers among different histological types. To the best of our knowledge, this is the first study to show the potential causative mechanism of the altered expression of miR-31 and suggest its potentially diverse significance in the different histological types of lung cancers.
|
| 巻・号 |
9(6)
|
| ページ |
e100581
|
| 公開日 |
2014-1-1
|
| DOI |
10.1371/journal.pone.0100581
|
| PII |
PONE-D-14-03612
|
| PMID |
24978700
|
| PMC |
PMC4076198
|
| MeSH |
Adenocarcinoma / genetics*
Adenocarcinoma / pathology
Adenocarcinoma / surgery
Allelic Imbalance
Carcinogenesis / genetics
Carcinogenesis / pathology
Carcinoma, Large Cell / genetics*
Carcinoma, Large Cell / pathology
Carcinoma, Large Cell / surgery
Carcinoma, Small Cell / genetics*
Carcinoma, Small Cell / pathology
Carcinoma, Small Cell / surgery
Carcinoma, Squamous Cell / genetics*
Carcinoma, Squamous Cell / pathology
Carcinoma, Squamous Cell / surgery
Cell Line, Tumor
Gene Dosage
Gene Expression Regulation, Neoplastic*
Genetic Loci
Genetic Pleiotropy
Humans
Lung Neoplasms / genetics*
Lung Neoplasms / pathology
Lung Neoplasms / surgery
MicroRNAs / genetics*
|
| IF |
2.74
|
| 引用数 |
10
|
|
WOS 分野
|
ONCOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
LC-2/ad(RCB0440)
Lu-130(RCB0465)
Lu-135(RCB0468)
Lu-139(RCB0469)
Lu-140(RCB0470) |
