論文 - 詳細
| RRC ID | 45201 |
|---|---|
| 著者 | Nakajima M, Takahashi A, Tsuji T, Karasugi T, Baba H, Uchida K, Kawabata S, Okawa A, Shindo S, Takeuchi K, Taniguchi Y, Maeda S, Kashii M, Seichi A, Nakajima H, Kawaguchi Y, Fujibayashi S, Takahata M, Tanaka T, Watanabe K, Kida K, Kanchiku T, Ito Z, Mori K, Kaito T, Kobayashi S, Yamada K, Takahashi M, Chiba K, Matsumoto M, Furukawa K, Kubo M, Toyama Y, Genetic Study Group of Investigation Committee on Ossification of the Spinal Ligaments, Ikegawa S. |
| タイトル | A genome-wide association study identifies susceptibility loci for ossification of the posterior longitudinal ligament of the spine. |
| ジャーナル | Nat Genet |
| Abstract |
Ossification of the posterior longitudinal ligament of the spine (OPLL) is a common spinal disorder among the elderly that causes myelopathy and radiculopathy. To identify genetic factors for OPLL, we performed a genome-wide association study (GWAS) in ∼8,000 individuals followed by a replication study using an additional ∼7,000 individuals. We identified six susceptibility loci for OPLL: 20p12.3 (rs2423294: P = 1.10 × 10(-13)), 8q23.1 (rs374810: P = 1.88 × 10(-13)), 12p11.22 (rs1979679: P = 4.34 × 10(-12)), 12p12.2 (rs11045000: P = 2.95 × 10(-11)), 8q23.3 (rs13279799: P = 1.28 × 10(-10)) and 6p21.1 (rs927485: P = 9.40 × 10(-9)). Analyses of gene expression in and around the loci suggested that several genes are involved in OPLL etiology through membranous and/or endochondral ossification processes. Our results bring new insight to the etiology of OPLL. |
| 巻・号 | 46(9) |
| ページ | 1012-6 |
| 公開日 | 2014-9-1 |
| DOI | 10.1038/ng.3045 |
| PII | ng.3045 |
| PMID | 25064007 |
| MeSH | Case-Control Studies Female Genetic Loci* Genetic Predisposition to Disease Genome-Wide Association Study / methods Humans Male Middle Aged Ossification of Posterior Longitudinal Ligament / genetics* Ossification of Posterior Longitudinal Ligament / pathology Polymorphism, Single Nucleotide Spine / pathology |
| IF | 27.605 |
| 引用数 | 51 |
| WOS 分野 | GENETICS & HEREDITY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 8 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | ATDC5(RCB0565) |