論文 - 詳細
| RRC ID | 45306 |
|---|---|
| 著者 | Ishii J, Sato H, Yazawa T, Shishido-Hara Y, Hiramatsu C, Nakatani Y, Kamma H. |
| タイトル | Class III/IV POU transcription factors expressed in small cell lung cancer cells are involved in proneural/neuroendocrine differentiation. |
| ジャーナル | Pathol Int |
| Abstract |
One-third of lung malignancies demonstrate a proneural/neuroendocrine phenotype or type of differentiation. However, it has not been clearly elucidated how proneural/neuroendocrine differentiation is controlled in lung cancers. We recently demonstrated that the POU3F2 gene plays a significant role in proneural/neuroendocrine differentiation of lung cancers. Because class III POU genes (POU3F1, POU3F2, POU3F3, and POU3F4) and class IV POU genes (POU4F1, POU4F2, and POU4F3) share similar properties in neural development, we analyzed the association between class III/IV POU genes and a proneural/neuroendocrine phenotype in lung cancers using seven small cell lung cancer (SCLC) cell lines and twelve non-SCLC (NSCLC) cell lines. Class III/IV POU gene expression was generally restricted to SCLC cells. However, the forced expression of class III/IV POU genes in the NSCLC cell lines induced the expression of neuroendocrine-specific markers (neural call adhesion molecule 1, synaptophysin, and chromogranin A) and proneural transcription factors (achaete-scute homolog-like 1, NeuroD1, and thyroid transcription factor 1) in various degrees. Furthermore, each class III/IV POU gene induced other class III/IV POU genes, suggesting the mutual induction of class III/IV POU genes. These findings suggest that the expression of class III/IV POU genes is important for the proneural/neuroendocrine differentiation of lung cancer cells. |
| 巻・号 | 64(9) |
| ページ | 415-22 |
| 公開日 | 2014-9-1 |
| DOI | 10.1111/pin.12198 |
| PMID | 25243889 |
| MeSH | Biomarkers, Tumor / genetics Biomarkers, Tumor / metabolism* Carcinoma, Neuroendocrine / metabolism* Carcinoma, Neuroendocrine / pathology Cell Differentiation Cell Line, Tumor Gene Expression Regulation, Neoplastic Humans Lung / pathology Lung Neoplasms / metabolism* Lung Neoplasms / pathology Neuroendocrine Cells / pathology POU Domain Factors / genetics POU Domain Factors / metabolism* Phenotype Small Cell Lung Carcinoma / metabolism* Small Cell Lung Carcinoma / pathology Transgenes |
| IF | 2.11 |
| 引用数 | 10 |
| WOS 分野 | PATHOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | PC-9(RCB4455) |