Reference - Detail
| RRC ID | 45329 |
|---|---|
| Author | Tsukamoto S, Takeuchi T, Kawabata T, Kato H, Yamakuma M, Matsuo K, El-Desoky AH, Losung F, Mangindaan RE, de Voogd NJ, Arata Y, Yokosawa H. |
| Title | Halenaquinone inhibits RANKL-induced osteoclastogenesis. |
| Journal | Bioorg Med Chem Lett |
| Abstract |
Halenaquinone was isolated from the marine sponge Petrosia alfiani as an inhibitor of osteoclastogenic differentiation of murine RAW264 cells. It inhibited the RANKL (receptor activator of nuclear factor-κB ligand)-induced upregulation of TRAP (tartrate-resistant acid phosphatase) activity as well as the formation of multinuclear osteoclasts. In addition, halenaquinone substantially suppressed RANKL-induced IκB degradation and Akt phosphorylation. Thus, these results suggest that halenaquinone inhibits RANKL-induced osteoclastogenesis at least by suppressing the NF-κB and Akt signaling pathways. |
| Volume | 24(22) |
| Pages | 5315-7 |
| Published | 2014-11-15 |
| DOI | 10.1016/j.bmcl.2014.09.043 |
| PII | S0960-894X(14)00986-X |
| PMID | 25278237 |
| MeSH | Animals Cell Differentiation / drug effects Cell Line I-kappa B Proteins / metabolism Mice Osteoclasts / cytology Osteoclasts / drug effects Osteoclasts / metabolism Osteogenesis / drug effects Petrosia / chemistry Petrosia / metabolism Phosphorylation / drug effects Proto-Oncogene Proteins c-akt / metabolism Quinones / chemistry* Quinones / isolation & purification Quinones / pharmacology RANK Ligand / toxicity Signal Transduction / drug effects |
| IF | 2.572 |
| Times Cited | 10 |
| WOS Category | CHEMISTRY, MEDICINAL CHEMISTRY, ORGANIC |
| Resource | |
| Human and Animal Cells | RAW 264(RCB0535) |