論文 - 詳細
| RRC ID | 45349 |
|---|---|
| 著者 | Sugimoto H, Watanabe K, Toyama T, Takahashi SS, Sugiyama S, Lee MC, Hamada N. |
| タイトル | Inhibitory effects of French pine bark extract, Pycnogenol®, on alveolar bone resorption and on the osteoclast differentiation. |
| ジャーナル | Phytother Res |
| Abstract |
Pycnogenol(®) (PYC) is a standardized bark extract from French maritime pine (Pinus pinaster Aiton). We examined the inhibitory effects of PYC on alveolar bone resorption, which is a characteristic feature of periodontitis, induced by Porphyromonas gingivalis (P. gingivalis) and osteoclast differentiation. In rat periodontitis model, rats were divided into four groups: group A served as the non-infected control, group B was infected orally with P. gingivalis ATCC 33277, group C was administered PYC in the diet (0.025%: w/w), and group D was infected with P. gingivalis and administered PYC. Administration of PYC along with P. gingivalis infection significantly reduced alveolar bone resorption. Treatment of P. gingivalis with 1 µg/ml PYC reduced the number of viable bacterial cells. Addition of PYC to epithelial cells inhibited adhesion and invasion by P. gingivalis. The effect of PYC on osteoclast formation was confirmed by tartrate-resistant acid phosphatase staining. PYC treatment significantly inhibited osteoclast formation. Addition of PYC (1-100 µg/ml) to purified osteoclasts culture induced cell apoptosis. These results suggest that PYC may prevent alveolar bone resorption through its antibacterial activity against P. gingivalis and by suppressing osteoclastogenesis. Therefore, PYC may be useful as a therapeutic and preventative agent for bone diseases such as periodontitis. |
| 巻・号 | 29(2) |
| ページ | 251-9 |
| 公開日 | 2015-2-1 |
| DOI | 10.1002/ptr.5245 |
| PMID | 25336411 |
| MeSH | Acid Phosphatase Alveolar Bone Loss / prevention & control* Animals Anti-Bacterial Agents / pharmacology Bone and Bones / drug effects Cell Differentiation / drug effects Cell Line Cells, Cultured Epithelial Cells / drug effects Flavonoids / pharmacology* Gingiva / cytology Humans Isoenzymes Male Mice, Inbred BALB C Osteoclasts / drug effects* Periodontitis / microbiology Periodontitis / prevention & control Pinus / chemistry* Plant Bark / chemistry Plant Extracts Porphyromonas gingivalis / drug effects Rats, Sprague-Dawley Tartrate-Resistant Acid Phosphatase |
| IF | 4.087 |
| 引用数 | 4 |
| WOS 分野 | CHEMISTRY, MEDICINAL PHARMACOLOGY & PHARMACY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Youtube |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | MC3T3-G2/PA6(RCB1127) |