論文 - 詳細
| RRC ID | 45358 |
|---|---|
| 著者 | Kudo H, Wada H, Sasaki H, Tsuji H, Otsuka R, Baghdadi M, Kojo S, Chikaraishi T, Seino K. |
| タイトル | Induction of macrophage-like immunosuppressive cells from mouse ES cells that contribute to prolong allogeneic graft survival. |
| ジャーナル | PLoS One |
| Abstract |
Recent progress in regenerative medicine has enabled the utilization of pluripotent stem cells (PSCs) such as embryonic stem cells (ESCs) as a donor resource for transplantation. However, immune suppression is still needed when the donor-recipient combination is allogeneic. Protection of ESCs-derived grafts from host immune response might be achieved thought the utilization of immunosuppressive cells generated from ESCs. In the present study, we show that a certain fraction of immunosuppressive cells can be generated from ESCs and help to suppress immune response against allogeneic grafts. ESCs-derived suppressor cells (ES-SCs) resembled macrophages in terms of cell surface molecule and gene expressions. Furthermore, gene expression analysis including microarray showed that ES-SCs have M1/M2 hybrid phenotype with high expression of genes correlated to immunosuppression of T cell response. Indeed, ES-SCs were effective to block allogeneic T cell proliferation in a nitric oxide-dependent manner, and prolonged the survival of ESCs-derived embryoid bodies or cardiomyocytes grafts transplanted into mouse kidney capsule. Thus, we consider the potential use of these ESCs-derived macrophage-like immunosuppressive cells as cellular therapies to promote long-term graft survival in future therapies. |
| 巻・号 | 9(10) |
| ページ | e111826 |
| 公開日 | 2014-1-1 |
| DOI | 10.1371/journal.pone.0111826 |
| PII | PONE-D-14-34143 |
| PMID | 25356669 |
| PMC | PMC4214817 |
| MeSH | Animals Cell Proliferation Dendritic Cells / cytology Female Graft Survival / immunology* Immunosuppression Therapy* Isoantigens / immunology Macrophages / cytology* Mice Mice, Inbred C3H Mouse Embryonic Stem Cells / cytology* Myocytes, Cardiac / cytology Myocytes, Cardiac / transplantation* Phenotype T-Lymphocytes / cytology Transplantation, Homologous |
| IF | 2.74 |
| 引用数 | 7 |
| WOS 分野 | IMMUNOLOGY |
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| リソース情報 | |
| ヒト・動物細胞 | OP9(RCB1124) |