RRC ID 45390
Author Yoshida H, Watanabe H, Ishida A, Watanabe W, Narumi K, Atsumi T, Sugita C, Kurokawa M.
Title Naringenin suppresses macrophage infiltration into adipose tissue in an early phase of high-fat diet-induced obesity.
Journal Biochem. Biophys. Res. Commun.
Abstract Obese adipose tissue is characterized by increased macrophage infiltration, which results in chronic inflammation in adipose tissue and leads to obesity-related diseases such as type 2 diabetes mellitus and atherosclerosis. The regulation of macrophage infiltration into adipose tissue is an important strategy for preventing and treating obesity-related diseases. In this study, we report that naringenin, a citrus flavonoid, suppressed macrophage infiltration into adipose tissue induced by short-term (14 days) feeding of a high-fat diet in mice; although naringenin did not show any differences in high-fat diet-induced changes of serum biochemical parameters in this short administration period. Naringenin suppressed monocyte chemoattractant protein-1 (MCP-1) in adipose tissue, and this effect was mediated in part through inhibition of c-Jun NH2-terminal kinase pathway. Naringenin also inhibited MCP-1 expression in adipocytes, macrophages, and a co-culture of adipocytes and macrophages. Our results suggest a mechanism by which daily consumption of naringenin may exhibit preventive effects on obesity-related diseases.
Volume 454(1)
Pages 95-101
Published 2014-11-7
DOI 10.1016/j.bbrc.2014.10.038
PII S0006-291X(14)01836-1
PMID 25450363
MeSH 3T3-L1 Cells Adipocytes / drug effects Adipocytes / metabolism Adipose Tissue / drug effects* Adipose Tissue / metabolism Adipose Tissue / pathology* Animals Anthracenes / pharmacology Cell Line Chemokine CCL2 / biosynthesis Chemokine CCL2 / genetics Diabetes Mellitus, Type 2 / prevention & control Diet, High-Fat / adverse effects* Flavanones / administration & dosage Flavanones / pharmacology* MAP Kinase Signaling System / drug effects Macrophages / drug effects* Macrophages / pathology* Male Mice Mice, Inbred C57BL Obesity / drug therapy* Obesity / etiology Obesity / pathology* RNA, Messenger / genetics RNA, Messenger / metabolism Time Factors
IF 2.705
Times Cited 11
Human and Animal Cells