論文 - 詳細
| RRC ID | 45390 |
|---|---|
| 著者 | Yoshida H, Watanabe H, Ishida A, Watanabe W, Narumi K, Atsumi T, Sugita C, Kurokawa M. |
| タイトル | Naringenin suppresses macrophage infiltration into adipose tissue in an early phase of high-fat diet-induced obesity. |
| ジャーナル | Biochem Biophys Res Commun |
| Abstract |
Obese adipose tissue is characterized by increased macrophage infiltration, which results in chronic inflammation in adipose tissue and leads to obesity-related diseases such as type 2 diabetes mellitus and atherosclerosis. The regulation of macrophage infiltration into adipose tissue is an important strategy for preventing and treating obesity-related diseases. In this study, we report that naringenin, a citrus flavonoid, suppressed macrophage infiltration into adipose tissue induced by short-term (14 days) feeding of a high-fat diet in mice; although naringenin did not show any differences in high-fat diet-induced changes of serum biochemical parameters in this short administration period. Naringenin suppressed monocyte chemoattractant protein-1 (MCP-1) in adipose tissue, and this effect was mediated in part through inhibition of c-Jun NH2-terminal kinase pathway. Naringenin also inhibited MCP-1 expression in adipocytes, macrophages, and a co-culture of adipocytes and macrophages. Our results suggest a mechanism by which daily consumption of naringenin may exhibit preventive effects on obesity-related diseases. |
| 巻・号 | 454(1) |
| ページ | 95-101 |
| 公開日 | 2014-11-7 |
| DOI | 10.1016/j.bbrc.2014.10.038 |
| PII | S0006-291X(14)01836-1 |
| PMID | 25450363 |
| MeSH | 3T3-L1 Cells Adipocytes / drug effects Adipocytes / metabolism Adipose Tissue / drug effects* Adipose Tissue / metabolism Adipose Tissue / pathology* Animals Anthracenes / pharmacology Cell Line Chemokine CCL2 / biosynthesis Chemokine CCL2 / genetics Diabetes Mellitus, Type 2 / prevention & control Diet, High-Fat / adverse effects* Flavanones / administration & dosage Flavanones / pharmacology* MAP Kinase Signaling System / drug effects Macrophages / drug effects* Macrophages / pathology* Male Mice Mice, Inbred C57BL Obesity / drug therapy* Obesity / etiology Obesity / pathology* RNA, Messenger / genetics RNA, Messenger / metabolism Time Factors |
| IF | 2.985 |
| 引用数 | 24 |
| WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ヒト・動物細胞 | RAW 264(RCB0535) |