Reference - Detail
| RRC ID | 45436 |
|---|---|
| Author | Tang H, Mahmoud NF, Mori Y. |
| Title | Maturation of human herpesvirus 6A glycoprotein O requires coexpression of glycoprotein H and glycoprotein L. |
| Journal | J Virol |
| Abstract |
Glycoprotein O (gO) is conserved among betaherpesviruses, but little is known about the maturation process of gO in human herpesvirus 6 (HHV-6). We found that HHV-6 gO maturation was accompanied by cleavage of its carboxyl terminus and required coexpression of gH and gL, which promoted the export of gO out of the endoplasmic reticulum (ER). Finally, we also found that gO was not required for HHV-6A growth in T cells. |
| Volume | 89(9) |
| Pages | 5159-63 |
| Published | 2015-5-1 |
| DOI | 10.1128/JVI.00140-15 |
| PII | JVI.00140-15 |
| PMID | 25694589 |
| PMC | PMC4403471 |
| MeSH | Cells, Cultured Gene Expression Herpesvirus 6, Human / physiology* Humans Protein Processing, Post-Translational* T-Lymphocytes / virology Viral Envelope Proteins / metabolism* Virus Replication* |
| IF | 4.501 |
| Times Cited | 7 |
| WOS Category | VIROLOGY |
| Resource | |
| Cord blood stem cells for research | |