論文 - 詳細
| RRC ID | 45493 |
|---|---|
| 著者 | Kumai T, Ohkuri T, Nagato T, Matsuda Y, Oikawa K, Aoki N, Kimura S, Celis E, Harabuchi Y, Kobayashi H. |
| タイトル | Targeting HER-3 to elicit antitumor helper T cells against head and neck squamous cell carcinoma. |
| ジャーナル | Sci Rep |
| Abstract |
HER-3 expression has been reported to act as an important oncoprotein in head and neck squamous cell carcinoma. This protein is known to control tumor proliferation and acquisition of resistance by tumor cells towards EGFR inhibitors, therefore, development of a HER-3-targeted therapy is desirable. In this study, we found that HER-3 expression on tumor cells was increased after EGFR inhibition. To establish a novel therapeutic approach for HER-3-positive head and neck carcinoma, we identified a HER-3 helper epitope that could elicit effective helper T cell responses to the naturally processed HER-3-derived epitope presented in a HER-3 expressing tumors. This epitope induced potent cytolytic activity of CD4 T cells against such tumor cells. Moreover, pan HER-family tyrosine kinase inhibitor augmented the responses of HER-3-reactive CD4 T cells via upregulation of HLA-DR protein on the surface of tumor cells. Our results supports the validity of CD4 T cell-dependent HER-3-targeted therapy combined with a broad inhibitor of HER-family. |
| 巻・号 | 5 |
| ページ | 16280 |
| 公開日 | 2015-11-5 |
| DOI | 10.1038/srep16280 |
| PII | srep16280 |
| PMID | 26538233 |
| PMC | PMC4633732 |
| MeSH | Animals CD4-Positive T-Lymphocytes / drug effects CD4-Positive T-Lymphocytes / immunology CD4-Positive T-Lymphocytes / metabolism Carcinoma, Squamous Cell / drug therapy* Carcinoma, Squamous Cell / immunology Carcinoma, Squamous Cell / metabolism Cell Line Cell Line, Tumor Epitopes, T-Lymphocyte / drug effects Epitopes, T-Lymphocyte / immunology Epitopes, T-Lymphocyte / metabolism ErbB Receptors / metabolism HLA-DR Antigens / metabolism Head and Neck Neoplasms / drug therapy* Head and Neck Neoplasms / immunology Head and Neck Neoplasms / metabolism Humans Jurkat Cells Lymphocyte Activation / drug effects Lymphocyte Activation / immunology Mice Protein Kinase Inhibitors / pharmacology* Receptor, ErbB-3 / metabolism* T-Lymphocytes, Helper-Inducer / drug effects* T-Lymphocytes, Helper-Inducer / immunology T-Lymphocytes, Helper-Inducer / metabolism Up-Regulation / drug effects |
| IF | 3.998 |
| 引用数 | 6 |
| WOS 分野 | ONCOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | HSC-3(RCB1975) HSC-4(RCB1902) Sa3(RCB0980) LU65(RCB1967) |