| RRC ID |
45511
|
| Author |
Matsuura N, Tamehiro N, Andoh T, Kawashima A, Ubukata M.
|
| Title |
Indocarbazostatin and indocarbazostatin B, novel inhibitors of NGF-induced neuronal differentiation in PC12 cells. I. Screening, taxonomy, fermentation and biological activities.
|
| Journal |
J Antibiot (Tokyo)
|
| Abstract |
During the course of our screening for modulators of signal transduction of mammalian cells, we discovered two novel indolocarbazole antibiotics, indocarbazostatin and indocabazostatin B, from a culture broth of a Streptomyces sp. as inhibitors of NGF-induced neuronal differentiation in rat pheochromocytoma PC12 cells. Indocarbazostatin and indocarbazostatin B inhibited NGF-induced neurite outgrowth from PC12 cells at 6 nM and 24 nM, respectively, whereas K-252a inhibited at 200 nM under our assay conditions.
|
| Volume |
55(4)
|
| Pages |
355-62
|
| Published |
2002-4-1
|
| DOI |
10.7164/antibiotics.55.355
|
| PMID |
12061542
|
| MeSH |
Animals
Carbazoles / pharmacology*
Cell Differentiation / drug effects*
Culture Media
Fermentation
Growth Inhibitors / pharmacology*
Indoles / pharmacology*
Nerve Growth Factor / antagonists & inhibitors*
Neurons / cytology
Neurons / drug effects*
PC12 Cells
Rats
Streptomyces / classification
Streptomyces / growth & development
Streptomyces / metabolism*
|
| IF |
2.668
|
| Times Cited |
14
|
|
WOS Category
|
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
PHARMACOLOGY & PHARMACY
IMMUNOLOGY
MICROBIOLOGY
|
| Resource |
| Human and Animal Cells |
PC-12(RCB0009) |
