論文 - 詳細
| RRC ID | 45531 |
|---|---|
| 著者 | Bohr T, Nelson CR, Klee E, Bhalla N. |
| タイトル | Spindle assembly checkpoint proteins regulate and monitor meiotic synapsis in C. elegans. |
| ジャーナル | J Cell Biol |
| Abstract |
Homologue synapsis is required for meiotic chromosome segregation, but how synapsis is initiated between chromosomes is poorly understood. In Caenorhabditis elegans, synapsis and a checkpoint that monitors synapsis depend on pairing centers (PCs), cis-acting loci that interact with nuclear envelope proteins, such as SUN-1, to access cytoplasmic microtubules. Here, we report that spindle assembly checkpoint (SAC) components MAD-1, MAD-2, and BUB-3 are required to negatively regulate synapsis and promote the synapsis checkpoint response. Both of these roles are independent of a conserved component of the anaphase-promoting complex, indicating a unique role for these proteins in meiotic prophase. MAD-1 and MAD-2 localize to the periphery of meiotic nuclei and interact with SUN-1, suggesting a role at PCs. Consistent with this idea, MAD-1 and BUB-3 require full PC function to inhibit synapsis. We propose that SAC proteins monitor the stability of pairing, or tension, between homologues to regulate synapsis and elicit a checkpoint response. |
| 巻・号 | 211(2) |
| ページ | 233-42 |
| 公開日 | 2015-10-26 |
| DOI | 10.1083/jcb.201409035 |
| PII | jcb.201409035 |
| PMID | 26483555 |
| PMC | PMC4621841 |
| MeSH | Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Cell Cycle Proteins / genetics Cell Cycle Proteins / metabolism* Cell Nucleus / metabolism Chromosome Pairing* Chromosome Segregation Chromosomes / metabolism Dyneins / genetics Dyneins / metabolism Mad2 Proteins / genetics Mad2 Proteins / metabolism* Meiosis* Nuclear Proteins / genetics Nuclear Proteins / metabolism* RNA Interference RNA, Small Interfering Receptors, Cytoplasmic and Nuclear / metabolism Spindle Apparatus / metabolism* |
| IF | 8.811 |
| 引用数 | 6 |
| WOS 分野 | CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 6 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1458 tm3039 tm2190 |