論文 - 詳細
| RRC ID | 45544 |
|---|---|
| 著者 | Cohen ML, Kim S, Morita K, Kim SH, Han M. |
| タイトル | The GATA factor elt-1 regulates C. elegans developmental timing by promoting expression of the let-7 family microRNAs. |
| ジャーナル | PLoS Genet |
| Abstract |
Postembryonic development in Caenorhabditis elegans is a powerful model for the study of the temporal regulation of development and for the roles of microRNAs in controlling gene expression. Stable switch-like changes in gene expression occur during development as stage-specific microRNAs are expressed and subsequently down-regulate other stage-specific factors, driving developmental progression. Key genes in this regulatory network are phylogenetically conserved and include the post-transcriptional microRNA repressor LIN-28; the nuclear hormone receptor DAF-12; and the microRNAs LIN-4, LET-7, and the three LET-7 family miRNAs (miR-48, miR-84, and miR-241). DAF-12 is known to regulate transcription of miR-48, miR-84 and miR-241, but its contribution is insufficient to account for all of the transcriptional regulation implied by the mutant phenotypes. In this work, the GATA-family transcription factor ELT-1 is identified from a genetic enhancer screen as a regulator of developmental timing in parallel to DAF-12, and is shown to do so by promoting the expression of the LET-7, miR-48, miR-84, and miR-241 microRNAs. The role of ELT-1 in developmental timing is shown to be separate from its role in cell-fate maintenance during post-embryonic development. In addition, analysis of Chromatin Immnoprecipitation (ChIP) data from the modENCODE project and this work suggest that the contribution of ELT-1 to the control of let-7 family microRNA expression is likely through direct transcription regulation. |
| 巻・号 | 11(3) |
| ページ | e1005099 |
| 公開日 | 2015-3-1 |
| DOI | 10.1371/journal.pgen.1005099 |
| PII | PGENETICS-D-14-00018 |
| PMID | 25816370 |
| PMC | PMC4376641 |
| MeSH | Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / growth & development Caenorhabditis elegans Proteins / biosynthesis* Caenorhabditis elegans Proteins / genetics Cell Differentiation / genetics* GATA Transcription Factors / biosynthesis* GATA Transcription Factors / genetics Gene Expression Regulation, Developmental MicroRNAs / biosynthesis* MicroRNAs / genetics Mutation Receptors, Cytoplasmic and Nuclear / genetics Transcription, Genetic* |
| IF | 5.175 |
| 引用数 | 8 |
| WOS 分野 | GENETICS & HEREDITY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 8 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm4063 |