論文 - 詳細
| RRC ID | 45603 |
|---|---|
| 著者 | Kim KD, Tanizawa H, Iwasaki O, Noma K. |
| タイトル | Transcription factors mediate condensin recruitment and global chromosomal organization in fission yeast. |
| ジャーナル | Nat Genet |
| Abstract |
It is becoming clear that structural-maintenance-of-chromosomes (SMC) complexes such as condensin and cohesin are involved in three-dimensional genome organization, yet their exact roles in functional organization remain unclear. We used chromatin interaction analysis by paired-end tag sequencing (ChIA-PET) to comprehensively identify genome-wide associations mediated by condensin and cohesin in fission yeast. We found that although cohesin and condensin often bind to the same loci, they direct different association networks and generate small and larger chromatin domains, respectively. Cohesin mediates associations between loci positioned within 100 kb of each other; condensin can drive longer-range associations. Moreover, condensin, but not cohesin, connects cell cycle-regulated genes bound by mitotic transcription factors. This study describes the different functions of condensin and cohesin in genome organization and how specific transcription factors function in condensin loading, cell cycle-dependent genome organization and mitotic chromosome organization to support faithful chromosome segregation. |
| 巻・号 | 48(10) |
| ページ | 1242-52 |
| 公開日 | 2016-10-1 |
| DOI | 10.1038/ng.3647 |
| PII | ng.3647 |
| PMID | 27548313 |
| PMC | PMC5042855 |
| MeSH | Adenosine Triphosphatases / metabolism* Binding Sites Cell Cycle Proteins / metabolism Chromatin / metabolism Chromosomal Proteins, Non-Histone / metabolism Chromosomes, Fungal* DNA-Binding Proteins / metabolism* GATA Transcription Factors / metabolism* Genes, Fungal Genes, cdc Mitosis Multiprotein Complexes / metabolism* Nuclear Proteins / metabolism Phosphoproteins / metabolism Protein Domains Schizosaccharomyces / genetics* Schizosaccharomyces / metabolism Schizosaccharomyces pombe Proteins / metabolism* Transcription Factors / metabolism* |
| IF | 27.605 |
| 引用数 | 31 |
| WOS 分野 | GENETICS & HEREDITY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 24 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 酵母 | S. pombe strains |