論文 - 詳細
| RRC ID | 45636 |
|---|---|
| 著者 | Ruijtenberg S, van den Heuvel S. |
| タイトル | G1/S Inhibitors and the SWI/SNF Complex Control Cell-Cycle Exit during Muscle Differentiation. |
| ジャーナル | Cell |
| Abstract |
The transition from proliferating precursor cells to post-mitotic differentiated cells is crucial for development, tissue homeostasis, and tumor suppression. To study cell-cycle exit during differentiation in vivo, we developed a conditional knockout and lineage-tracing system for Caenorhabditis elegans. Combined lineage-specific gene inactivation and genetic screening revealed extensive redundancies between previously identified cell-cycle inhibitors and the SWI/SNF chromatin-remodeling complex. Muscle precursor cells missing either SWI/SNF or G1/S inhibitor function could still arrest cell division, while simultaneous inactivation of these regulators caused continued proliferation and a C. elegans tumor phenotype. Further genetic analyses support that SWI/SNF acts in concert with hlh-1 MyoD, antagonizes Polycomb-mediated transcriptional repression, and suppresses cye-1 Cyclin E transcription to arrest cell division of muscle precursors. Thus, SWI/SNF and G1/S inhibitors provide alternative mechanisms to arrest cell-cycle progression during terminal differentiation, which offers insight into the frequent mutation of SWI/SNF genes in human cancers. |
| 巻・号 | 162(2) |
| ページ | 300-313 |
| 公開日 | 2015-7-16 |
| DOI | 10.1016/j.cell.2015.06.013 |
| PII | S0092-8674(15)00696-0 |
| PMID | 26144318 |
| MeSH | Animals Caenorhabditis elegans / cytology* Caenorhabditis elegans / growth & development* Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins / metabolism Cell Cycle Cell Differentiation Cell Lineage Cell Proliferation Chromosomal Proteins, Non-Histone / metabolism Muscle Proteins Muscles / cytology* Muscles / metabolism Myoblasts / cytology Myoblasts / metabolism Myogenic Regulatory Factors / metabolism Nuclear Proteins Polycomb-Group Proteins / metabolism Transcription Factors / metabolism |
| IF | 38.637 |
| 引用数 | 37 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 26 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm4567 |