論文 - 詳細
| RRC ID | 45656 |
|---|---|
| 著者 | Wei X, Howell AS, Dong X, Taylor CA, Cooper RC, Zhang J, Zou W, Sherwood DR, Shen K. |
| タイトル | The unfolded protein response is required for dendrite morphogenesis. |
| ジャーナル | Elife |
| Abstract |
Precise patterning of dendritic fields is essential for the formation and function of neuronal circuits. During development, dendrites acquire their morphology by exuberant branching. How neurons cope with the increased load of protein production required for this rapid growth is poorly understood. Here we show that the physiological unfolded protein response (UPR) is induced in the highly branched Caenorhabditis elegans sensory neuron PVD during dendrite morphogenesis. Perturbation of the IRE1 arm of the UPR pathway causes loss of dendritic branches, a phenotype that can be rescued by overexpression of the ER chaperone HSP-4 (a homolog of mammalian BiP/grp78). Surprisingly, a single transmembrane leucine-rich repeat protein, DMA-1, plays a major role in the induction of the UPR and the dendritic phenotype in the UPR mutants. These findings reveal a significant role for the physiological UPR in the maintenance of ER homeostasis during morphogenesis of large dendritic arbors. |
| 巻・号 | 4 |
| ページ | e06963 |
| 公開日 | 2015-6-8 |
| DOI | 10.7554/eLife.06963 |
| PMID | 26052671 |
| PMC | PMC4484204 |
| MeSH | Animals Caenorhabditis elegans / growth & development* Caenorhabditis elegans Proteins / metabolism Dendrites / physiology* Endoribonucleases / genetics Endoribonucleases / metabolism Membrane Proteins / metabolism Morphogenesis* Protein Biosynthesis* Unfolded Protein Response* |
| IF | 7.08 |
| 引用数 | 20 |
| WOS 分野 | BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm2482 |