論文 - 詳細
| RRC ID | 45660 |
|---|---|
| 著者 | Yamazoe-Umemoto A, Fujita K, Iino Y, Iwasaki Y, Kimura KD. |
| タイトル | Modulation of different behavioral components by neuropeptide and dopamine signalings in non-associative odor learning of Caenorhabditis elegans. |
| ジャーナル | Neurosci Res |
| Abstract |
An animal's behavior is modulated by learning; however, the behavioral component modulated by learning and the mechanisms of this modulation have not been fully understood. We show here that two types of neural signalings are required for the modulation of different behavioral components in non-associative odor learning in the nematode Caenorhabditis elegans. We have previously found that C. elegans avoid the repulsive odor 2-nonanone, and preexposure to the odor for 1h enhances the avoidance behavior as a type of non-associative learning. Systematic quantitative analyses of behavioral components revealed that the odor preexposure caused increases in average duration of straight migration ("runs") only when the animals were migrating away from the odor source within a certain range of bearing, which likely corresponds to odor decrement. Further, genetic analyses revealed that the genes for neuropeptide or dopamine signalings are both required for the enhanced odor avoidance. Neuropeptide signaling genes were required for the preexposure-dependent increase in run duration. In contrast, dopamine signaling genes were required not for the increase in run duration but likely for maintenance of run direction. Our results suggests that multiple behavioral components are regulated by different neuromodulators even in non-associative learning in C. elegans. |
| 巻・号 | 99 |
| ページ | 22-33 |
| 公開日 | 2015-10-1 |
| DOI | 10.1016/j.neures.2015.05.009 |
| PII | S0168-0102(15)00157-1 |
| PMID | 26068898 |
| MeSH | Animals Association Learning / physiology* Avoidance Learning / physiology* Behavior, Animal / physiology* Caenorhabditis elegans Caenorhabditis elegans Proteins / genetics Dopamine / metabolism* Neuropeptides / metabolism* Neurotransmitter Agents / metabolism Odorants* Signal Transduction / physiology |
| IF | 2.645 |
| 引用数 | 10 |
| WOS 分野 | NEUROSCIENCES |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1356 tm2261 |