論文 - 詳細
| RRC ID | 45726 |
|---|---|
| 著者 | Edwards TJ, Hammarlund M. |
| タイトル | Syndecan promotes axon regeneration by stabilizing growth cone migration. |
| ジャーナル | Cell Rep |
| Abstract |
Growth cones facilitate the repair of nervous system damage by providing the driving force for axon regeneration. Using single-neuron laser axotomy and in vivo time-lapse imaging, we show that syndecan, a heparan sulfate (HS) proteoglycan, is required for growth cone function during axon regeneration in C. elegans. In the absence of syndecan, regenerating growth cones form but are unstable and collapse, decreasing the effective growth rate and impeding regrowth to target cells. We provide evidence that syndecan has two distinct functions during axon regeneration: (1) a canonical function in axon guidance that requires expression outside the nervous system and depends on HS chains and (2) an intrinsic function in growth cone stabilization that is mediated by the syndecan core protein, independently of HS. Thus, syndecan is a regulator of a critical choke point in nervous system repair. |
| 巻・号 | 8(1) |
| ページ | 272-83 |
| 公開日 | 2014-7-10 |
| DOI | 10.1016/j.celrep.2014.06.008 |
| PII | S2211-1247(14)00476-8 |
| PMID | 25001284 |
| PMC | PMC4127196 |
| MeSH | Animals Caenorhabditis elegans / metabolism* Caenorhabditis elegans / physiology Growth Cones / metabolism* Growth Cones / physiology Nerve Regeneration* Syndecans / genetics Syndecans / metabolism* |
| IF | 8.109 |
| 引用数 | 24 |
| WOS 分野 | CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm734 tm3006 tm472 |