Reference - Detail
| RRC ID | 45746 |
|---|---|
| Author | Hisamoto N, Li C, Yoshida M, Matsumoto K. |
| Title | The C. elegans HGF/plasminogen-like protein SVH-1 has protease-dependent and -independent functions. |
| Journal | Cell Rep |
| Abstract |
Hepatocyte growth factor (HGF) and fibrinolytic serine protease plasminogen may have evolved from a common ancestor in vertebrates. This has been hard to ascertain, as no ancestral form has been identified in other lineages. In Caenorhabditis elegans, an HGF/plasminogen-like protein SVH-1 regulates axon regeneration via the HGF receptor homolog SVH-2. In this study, we report that both the svh-1 and svh-2 genes are conserved in many invertebrates. We also show that SVH-1 has an additional function, independent of SVH-2, which controls larval growth. SVH-1 protease activity is essential for larval growth, but not for axon regeneration. Deletion of svh-1 causes abnormal accumulation of FBL-1 protein, an extracellular matrix (ECM) component fibulin, around the pharynx, and this growth defect is partially suppressed by FBL-1 depletion. These results suggest that SVH-1 acts as both a growth factor and a protease, and they also provide insights into the evolution of HGF/plasminogen in animals. |
| Volume | 9(5) |
| Pages | 1628-1634 |
| Published | 2014-12-11 |
| DOI | 10.1016/j.celrep.2014.10.056 |
| PII | S2211-1247(14)00925-5 |
| PMID | 25464847 |
| MeSH | Animals Caenorhabditis elegans / enzymology* Caenorhabditis elegans / growth & development Caenorhabditis elegans Proteins / physiology* Calcium-Binding Proteins / metabolism Conserved Sequence Evolution, Molecular Gastrointestinal Motility Gene Expression Hepatocyte Growth Factor / genetics Intercellular Signaling Peptides and Proteins / physiology* Larva / enzymology Larva / growth & development Muscle Contraction Organ Specificity Pharynx / physiology Plasminogen / genetics |
| IF | 8.109 |
| Times Cited | 4 |
| WOS Category | CELL BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
|
| The most frequently cited source | X(Twitter) |
| Total number of mentions | 4 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm2646 tm737 |