論文 - 詳細
| RRC ID | 45753 |
|---|---|
| 著者 | Hwang AB, Ryu EA, Artan M, Chang HW, Kabir MH, Nam HJ, Lee D, Yang JS, Kim S, Mair WB, Lee C, Lee SS, Lee SJ. |
| タイトル | Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in Caenorhabditis elegans. |
| ジャーナル | Proc Natl Acad Sci U S A |
| Abstract |
Mild inhibition of mitochondrial respiration extends the lifespan of many species. In Caenorhabditis elegans, reactive oxygen species (ROS) promote longevity by activating hypoxia-inducible factor 1 (HIF-1) in response to reduced mitochondrial respiration. However, the physiological role and mechanism of ROS-induced longevity are poorly understood. Here, we show that a modest increase in ROS increases the immunity and lifespan of C. elegans through feedback regulation by HIF-1 and AMP-activated protein kinase (AMPK). We found that activation of AMPK as well as HIF-1 mediates the longevity response to ROS. We further showed that AMPK reduces internal levels of ROS, whereas HIF-1 amplifies the levels of internal ROS under conditions that increase ROS. Moreover, mitochondrial ROS increase resistance to various pathogenic bacteria, suggesting a possible association between immunity and long lifespan. Thus, AMPK and HIF-1 may control immunity and longevity tightly by acting as feedback regulators of ROS. |
| 巻・号 | 111(42) |
| ページ | E4458-67 |
| 公開日 | 2014-10-21 |
| DOI | 10.1073/pnas.1411199111 |
| PII | 1411199111 |
| PMID | 25288734 |
| PMC | PMC4210294 |
| MeSH | AMP-Activated Protein Kinases / metabolism* Aging Animals Caenorhabditis elegans / immunology Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / metabolism* Cell Respiration Feedback, Physiological* Homeostasis Iron / chemistry Longevity / physiology Mitochondria / metabolism Mutation Paraquat / chemistry Phosphorylation Reactive Oxygen Species / metabolism* Transcription Factors / metabolism* |
| IF | 9.412 |
| 引用数 | 80 |
| WOS 分野 | CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 16 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm2986 |