論文 - 詳細
| RRC ID | 45768 |
|---|---|
| 著者 | Kennedy LM, Grishok A. |
| タイトル | Neuronal migration is regulated by endogenous RNAi and chromatin-binding factor ZFP-1/AF10 in Caenorhabditis elegans. |
| ジャーナル | Genetics |
| Abstract |
Endogenous short RNAs and the conserved plant homeodomain (PHD) zinc-finger protein ZFP-1/AF10 regulate overlapping sets of genes in Caenorhabditis elegans, which suggests that they control common biological pathways. We have shown recently that the RNAi factor RDE-4 and ZFP-1 negatively modulate transcription of the insulin/PI3 signaling-dependent kinase PDK-1 to promote C. elegans fitness. Moreover, we have demonstrated that the insulin/IGF-1-PI3K-signaling pathway regulates the activity of the DAF-16/FOXO transcription factor in the hypodermis to nonautonomously promote the anterior migrations of the hermaphrodite-specific neurons (HSNs) during embryogenesis of C. elegans. In this study, we implicate the PHD-containing isoform of ZFP-1 and endogenous RNAi in the regulation of HSN migration. ZFP-1 affects HSN migration in part through its negative effect on pdk-1 transcription and modulation of downstream DAF-16 activity. We also identify a novel role for ZFP-1 and RNAi pathway components, including RDE-4, in the regulation of HSN migration in parallel with DAF-16. Therefore, the coordinated activities of DAF-16, ZFP-1, and endogenous RNAi contribute to gene regulation during development to ensure proper neuronal positioning. |
| 巻・号 | 197(1) |
| ページ | 207-20 |
| 公開日 | 2014-5-1 |
| DOI | 10.1534/genetics.114.162917 |
| PII | genetics.114.162917 |
| PMID | 24558261 |
| PMC | PMC4012481 |
| MeSH | Active Transport, Cell Nucleus Animals Caenorhabditis elegans / cytology Caenorhabditis elegans / embryology Caenorhabditis elegans / genetics* Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / chemistry Caenorhabditis elegans Proteins / metabolism* Cell Movement* Chromatin / metabolism* Forkhead Transcription Factors Neurons / cytology* Protein Isoforms / chemistry Protein Isoforms / metabolism Protein Structure, Tertiary RNA Interference* Species Specificity Subcutaneous Tissue / embryology Transcription Factors / chemistry Transcription Factors / metabolism* |
| IF | 4.015 |
| 引用数 | 3 |
| WOS 分野 | GENETICS & HEREDITY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1860 tm1637 tm892 |